Results 191 to 200 of about 21,533,267 (299)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Family Resilience and Family Adaptation in Caregivers of Disabled Older Adults: A Latent Profile Analysis. [PDF]

Geriatr Gerontol Int
Chen L, Yang L, Wang J, Huang Y, Ye J.
europepmc   +1 more source

Developmental trajectories of illness perception and influencing factors in patients with diabetic ketoacidosis

Huli yanjiu
ObjectiveTo analyze the developmental trajectories of illness perception in patients with diabetic ketoacidosis(DKA) and to analyze the influencing factors.MethodsA total of 197 hospitalized patients with DKA admitted to our hospital were selected as the
XU Yajuan, ZHOU Yuan
doaj  

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Early Adoption of Digital Devices and Change in Loneliness Over 10 Years Among Late Middle-Aged and Older Adults: Longitudinal Cohort Study. [PDF]

JMIR Form Res
Dahl Aslan AK, Gellerstedt M, Reynolds CA, Finkel D.   +3 more
europepmc   +1 more source

Symptom cluster trajectories during neoadjuvant chemotherapy and their association with postoperative recovery outcomes in rectal cancer patients

Huli yanjiu
ObjectiveTo investigate the trajectories of symptom clusters in rectal cancer patients undergoing neoadjuvant chemotherapy and to analyze their correlation with postoperative recovery indicators.MethodsA convenience sampling method was used to select 120
GUO Wenyue, LUO Jue, ZHANG Wen, ZHANG Xiaoju   +3 more
doaj  

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Association between intracatheter Ca²⁺ trajectory and extracorporeal circuit coagulation in unplanned early withdrawal among patients receiving CRRT: a retrospective cohort study. [PDF]

BMJ Open
Zhang Y, Ma J, Gao G, Zeng Y, Huang Y, Cheng C, Li J, Ding X, Li Z.   +8 more
europepmc   +1 more source