Results 221 to 230 of about 306,960 (301)

Heterogeneity in public attitudes and preferences for the deployment of aquifer thermal energy storage. [PDF]

Nat Energy
Liu T, Hanna R, Kountouris Y.
europepmc   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Probabilistic Clustering Using Multivariate Growth Mixture Model in Clinical Settings-A Scleroderma Example. [PDF]

Stat Med
Kim JS, Xu Y, Wallwork RS, Hummers LK, Shah AA, Zeger SL.   +5 more
europepmc   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Disentangling Heterogeneity in the Co-Developmental of Anxiety and Depression During the COVID-19 Pandemic: Insights From Cross-Lagged Panel Network. [PDF]

Depress Anxiety
Ma Z, Chen XY, Yu Z, Li Y, Zhao S, Wang D, Fan F.   +6 more
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Developmental Trajectories of Positive Expectancies of Cannabis Use Effects Among Early Adolescents: Longitudinal Observational Study Using Latent Class Growth Analysis.

JMIR Public Health Surveill
Qin WA, Seo DC, Jacobs W, Huang S, Elam KK.   +4 more
europepmc   +1 more source

An unfavorable biologic profile associated with decreased overall survival and cancer-specific survival in non-metastatic breast cancer: A latent class analysis. [PDF]

Transl Oncol
Falandry C, Hatse S, Brouwers B, Kenis C, Smeets A, Neven P, Cuerq C, Pamoukdjian F, Chikh K, Wildiers H.   +9 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Mental Health Profiles Based on Self-Regulation and Technology Use in the Digital Era in a Spanish-Speaking Sample: Latent Profile Analysis. [PDF]

JMIR Hum Factors
Garzón Umerenkova A, Alba Cabañas M, Malpica-Chavarria EA.   +2 more
europepmc   +1 more source