The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial [PDF]
BACKGROUND: Schizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about ...
Ascher-Svanum, H +6 more
core +2 more sources
Handgun carrying among youth in the United States [PDF]
Despite a wealth of research finding that adolescents who carry handguns are involved in risky behaviors, there has been little exploration into the heterogeneity of this behavior.
Boutwell, Brian B. +4 more
core +1 more source
Identification of Multivariate Responders and Non-Responders by using Bayesian Growth Curve Latent Class Models [PDF]
Summary We propose a multivariate growth curve mixture model that groups subjects on the basis of multiple symptoms measured repeatedly over time. Our model synthesizes features of two models. First, we follow Roy and Lin in relating the multiple symptoms at each time point to a single latent variable.
Benjamin E, Leiby +3 more
openaire +2 more sources
Introduction We examine whether distinct brain atrophy patterns (using brain parenchymal fraction [BPF]) differentially predict functional performance and decline in Alzheimer's disease (AD), and are independently moderated by (1) a key AD genetic risk ...
Shraddha Sapkota +5 more
doaj +1 more source
Serum Cystatin C Trajectory Is a Marker Associated With Diabetic Kidney Disease
ObjectiveTo explore the association of the trajectory of serum Cystatin C (Cysc) with diabetic kidney disease (DKD), a retrospective cohort study of Chinese subjects was carried out.MethodA review of 2,928 diabetes mellitus (DM) patients admitted to the ...
Nana Wang +5 more
doaj +1 more source
Behavioral risk profiles of homeschooled adolescents in the United States: a nationally representative examination of substance use related outcomes [PDF]
BACKGROUND: The homeschool population continues to grow in size and now accounts for 3.4% of all students in the United States. OBJECTIVE: Given the heterogeneous nature of the population, this study examines the relationship between different types of ...
Hodge, David R. +2 more
core +1 more source
Trajectories of Depressive Symptoms among Multicultural Adolescents in Korea: Longitudinal Analysis Using Latent Class Growth Model [PDF]
The purpose of this study was to investigate the trajectory of depressive symptoms in multicultural adolescents using longitudinal data, and to identify predictive factors related to depressive symptoms of multicultural adolescents using latent class analysis.
Min Kyung Song +2 more
openaire +2 more sources
Growth Mixture Modeling of Depression Symptoms Following Traumatic Brain Injury
Growth Mixture Modeling (GMM) was used to investigate the longitudinal trajectory of groups (classes) of depression symptoms, and how these groups were predicted by the covariates of age, sex, severity, and length of hospitalization following Traumatic ...
Rapson Gomez +3 more
doaj +1 more source
This cross-country four-year longitudinal study investigated the development of processing speed throughout primary school education. The analyses were conducted on data accumulated from 441 pupils in grades from 1 to 4 (aged 6.42 to 11.85 years) in ...
Tatiana Tikhomirova +3 more
doaj +1 more source
Distinguishing Asthma Phenotypes Using Machine Learning Approaches. [PDF]
Asthma is not a single disease, but an umbrella term for a number of distinct diseases, each of which are caused by a distinct underlying pathophysiological mechanism. These discrete disease entities are often labelled as asthma endotypes.
A Custovic +97 more
core +2 more sources

