Results 41 to 50 of about 254,793 (285)
Frontiers in Applied Mathematics and StatisticsBackgroundIdentifying heterogeneity in longitudinal data is critical for understanding diverse trajectories in clinical and epidemiological research. Traditional analytical methods often fail to distinguish latent subpopulations.
Harrid Nkhoma +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
A Latent Class Modeling Approach for Differentially Private Synthetic Data for Contingency Tables
The Journal of Privacy and Confidentiality, 2022 We present an approach to construct differentially private synthetic data for contingency tables. The algorithm achieves privacy by adding noise to selected summary counts, e.g., two-way margins of the contingency table, via the Geometric mechanism.
Michelle Nixon +3 more
doaj +2 more sources
EconometricsHeterogeneity in preferences can be addressed through various discrete choice modeling approaches. The random-parameter latent class (RLC) approach offers a desirable alternative for analysts due to its advantageous properties of separating classes with ...
Péter Czine +6 more
doaj +1 more source
Bayesian Variable Selection for Latent Class Models [PDF]
Biometrics, 2010 In this article we develop a latent class model with class probabilities that depend on subject-specific covariates. One of our major goals is to identify important predictors of latent classes. We consider methodology that allows estimation of latent classes while allowing for variable selection uncertainty.
Ghosh, Joyee +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A Zero-Inflated Box-Cox Normal Unipolar Item Response Model for Measuring Constructs of Psychopathology [PDF]
, 2018 This research introduces a latent class item response theory (IRT) approach for modeling item response data from zero-inflated, positively skewed, and arguably unipolar constructs of psychopathology. As motivating data, the authors use 4,925 responses to
Liu, Yang, Magnus, Brooke E.
core +1 more source
Handgun carrying among youth in the United States [PDF]
, 2016 Despite a wealth of research finding that adolescents who carry handguns are involved in risky behaviors, there has been little exploration into the heterogeneity of this behavior.
Boutwell, Brian B. +4 more
core +1 more source
Post‐COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuropsychiatric symptoms are among the most prevalent sequelae of COVID‐19, particularly among hospitalized patients. Recent research has identified volumetric brain changes associated with COVID‐19. However, it currently remains poorly understood how brain changes relate to post‐COVID fatigue and cognitive deficits.
Tim J. Hartung +190 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source