Results 41 to 50 of about 39,538 (265)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Multivariate Spatial Autoregressive Model with Latent Variables: Application to Economic Growth Modeling [PDF]

International Journal of Mathematical, Engineering and Management Sciences
Research involving causal relationships among latent variables that generally use structural equation modeling (SEM) analysis and spatial data simultaneously has an unavoidable impact on using spatial SEM analysis.
Anik Anekawati , Purhadi, Mohammad Rofik
doaj   +1 more source

Effects of APOEɛ4 genotype on age-associated change in cognitive functions among Japanese middle-aged and older adults: A 20-year follow-up study

Experimental Gerontology, 2023
Background and aims: Carriers of the apolipoprotein E ε4 allele (APOEɛ4) have an increased risk of developing dementia (e.g., Alzheimer's disease). However, it is less clear whether the APOEɛ4 might also be involved in cognitive aging among the non ...
Yukiko Nishita, Giovanni Sala, Mitsuru Shinohara, Chikako Tange, Fujiko Ando, Hiroshi Shimokata, Naoyuki Sato, Rei Otsuka   +7 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Mg-3Al-1Zn alloy deformed along different strain paths: Role of latent hardening

Journal of Magnesium and Alloys, 2023
The mechanical properties of magnesium alloy AZ31 were investigated experimentally with visco-plastic self-consistent modeling. Tension, compression and plane strain compression (PSC) tests were performed along 3 directions of a hot rolled plate, and the
Yao Cheng, Adrien Chapuis, Yunchang Xin, Qing Liu, Peidong Wu   +4 more
doaj   +1 more source

Latent Class Growth Modelling: A Tutorial [PDF]

Tutorials in Quantitative Methods for Psychology, 2009
The present work is an introduction to Latent Class Growth Modelling (LCGM). LCGM is a semi-parametric statistical technique used to analyze longitudinal data. It is used when the data follows a pattern of change in which both the strength and the direction of the relationship between the independent and dependent variables differ across cases.
Andruff, Heather, Carraro, Natasha, Thompson, Amanda, Gaudreau, Patrick, Louvet, Benoît   +4 more
openaire   +4 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Measuring the performance of LPA, LCGA, LGCM, and GMM in identifying the homogenous subgroups (latent classes) within the wider heterogeneous population of patients on DTG

Frontiers in Applied Mathematics and Statistics
BackgroundIdentifying heterogeneity in longitudinal data is critical for understanding diverse trajectories in clinical and epidemiological research. Traditional analytical methods often fail to distinguish latent subpopulations.
Harrid Nkhoma, Atupele Ngina Mulaga, Save Kumwenda, Mphatso Kamndaya   +3 more
doaj   +1 more source

Bayesian modeling of embryonic growth using latent variables [PDF]

Biostatistics, 2007
In a growth model, individuals move progressively through a series of states in which each state is indicative of developmental status. Interest lies in estimating the rate of progression through each state while incorporating covariates that might affect the transition rates.
James C, Slaughter, Amy H, Herring, Katherine E, Hartmann   +2 more
openaire   +2 more sources