Results 181 to 190 of about 59,541 (256)

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Interplay of Crystallization and Amorphous Spinodal Decomposition During Thermal Annealing of Organic Photoactive Layers

Advanced Science, EarlyView.
Phase‐Field simulations are carried out to elucidate nanomorphology formation mechanisms in organic photoactive layers under thermal annealing. The predicted bulk heterojunction structures are in excellent agreement with Scanning Electron Microscopy measurements.
Maxime Siber, Olivier J. J. Ronsin, Gitti L. Frey, Jens Harting   +3 more
wiley   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Dual Effect of Steric Hindrance in Non‐Aqueous Amine Absorbents: Navigating the Trade‐Off Between Kinetics and Thermodynamics for Efficient CO2 Capture

Advanced Science, EarlyView.
This study elucidates how steric hindrance in amines creates a dual effect in CO2 capture: it thermodynamically favors the reaction by shifting the pathway from carbamate to alkyl carbonate formation, increasing capacity and lowering regeneration heat, while simultaneously slightly slowing the kinetics.
Xiaoyi Gao, Bin Xu, Xi Tang, Muyi Li, Cong Luo, Fan Wu, Xiaoshan Li, Liqi Zhang, Wen Chen   +8 more
wiley   +1 more source

Investigation of Lactones as Innovative Bio-Sourced Phase Change Materials for Latent Heat Storage. [PDF]

Molecules, 2019
Ravotti R, Fellmann O, Lardon N, Fischer LJ, Stamatiou A, Worlitschek J.   +5 more
europepmc   +1 more source

In Situ Electrochemical Activation of Pseudo‐Layered NbS3 via Interlayer Expansion and Dual Redox for High Mg‐Ion Storage

Advanced Science, EarlyView.
A quasi‐1D pseudo‐layered NbS3 cathode for magnesium‐ion batteries can be created through electrochemically induced interlayer expansion. The widened ion‐transport channels enable fast magnesium ion diffusion and unlock coupled cationic‐anionic redox chemistry.
Pengcheng Jing, Atsushi Inoishi, Chengcheng Zhao, Eiichi Kobayashi, Peng Ren, Isaac Abrahams, Duncan H. Gregory   +6 more
wiley   +1 more source

Global Investigation of Soil Moisture and Latent Heat Flux Coupling Strength. [PDF]

Water Resour Res, 2018
Lei F, Crow WT, Holmes TRH, Hain C, Anderson MC.   +4 more
europepmc   +1 more source

Optoelectronic‐Driven van der Waals Ferroelectric Materials‐Based Memory Devices for Retinomorphic and In‐Sensory Hardware

Advanced Science, EarlyView.
2D ferroelectrics materials enabling non‐volatile polarization memory, optical excitability, and neuromorphic processing within a unified material and provides a mechanistic analysis of polarization‐induced band modulation, including photon‐assisted domain reorientation, switching kinetics, and interfacial dipole coupling that governs resistive ...
Parthasarathi Pal, Yeong‐Her Wang, Sanjay Kumar, Themis Prodromakis   +3 more
wiley   +1 more source

Neuromorphic Motor Control with Electrolyte‐Gated Organic Synaptic Transistors

Advanced Electronic Materials, EarlyView.
Electrolyte‐gated organic synaptic transistor (EGOST)‐based neuromorphic motor control systems integrate sensing, processing, and actuation by mimicking biological synapses. With advantages such as low power consumption, tunable synaptic plasticity, and mechanical flexibility, they are emerging as next‐generation core technologies for real‐time ...
Sung‐Hwan Kim, Ju‐Hyeok Yun, Hea‐Lim Park, Sin‐Hyung Lee   +3 more
wiley   +1 more source