Results 51 to 60 of about 244,800 (310)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Force Performance Analysis of Pile Behavior of the Lateral Load

Infrastructures, 2019
This study was focused on the performance of the pile force at the lateral load of an arched bridge. The effect of the compression of arch bridges creates a large horizontal load.
Touré Youssouf, Tianlai Yu, Dembélé Abdramane, Assogba Ogoubi Cyriaque, Diakité Youssouf   +4 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Analytical method for single pile under V-H-M combined loads in sand

Yantu gongcheng xuebao, 2017
The large-diameter monopiles of offshore wind turbines are always subjected to multiaxial loads. The design criteria for the vertical and lateral bearing behaviors of piles are designed independently, while lots of tests show that the vertical load has a
MU Lin-long 1, 2, KANG Xing-yu 1, 2, LI Wan 1, 2
doaj   +1 more source

Evaluation of the Spherical Flange Concept for a Rocket Engine [PDF]

, 2003
Due to the inherent tolerance variability of hardware, flange misalignments occur during installation of mating components for a liquid propellant rocket engine. Flange misalignments include axial, lateral, and angular offsets. If these misalignments are
Nichols, Jay, Stangeland, Maynard L., Tygielski, Philip, Urquidi, Ronald   +3 more
core   +1 more source

Consideration of the restriction of lateral contraction in the elastic behaviour of cohesive zone models

, 2015
Cohesive zone models do not consider the lateral contraction of adhesive layers under tensile loads. The constraint of the lateral contraction by the adherents which depends on the geometry of the adhesive layer has a major influence on the normal ...
Hesebeck, Olaf
core   +1 more source

Study of the effectiveness of outrigger system for high-rise composite buildings for cyclonic region [PDF]

, 2011
The demands of taller structures are becoming imperative almost everywhere in the world in addition to the challenges of material and labor cost, project time line etc.
Fatima, Tabassum, Fawzia, Sabrina, Nasir, Azhar   +2 more
core   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Shear-lag effect and its effect on the design of high-rise buildings

E3S Web of Conferences, 2018
For super high-rise buildings, the analysis and selection of suitable structural solutions are very important. The structure has not only to carry the gravity loads (self-weight, live load, etc.), but also to resist lateral loads (wind and earthquake ...
Dat Bui Thanh, Traykov Alexander, Traykova Marina   +2 more
doaj   +1 more source