Results 81 to 90 of about 285,303 (312)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Radiological study of the ossification process of medial clavicular epiphysis: the influence of sex and laterality

open access: yesFolia Morphologica
BACKGROUND: Radiological examination of bones such as the clavicle have been developed to estimate the age of an individual without valid identification or when suspected of providing inaccurate age.
Dominic Marera, Kapil Sewsaran Satyapal
doaj   +1 more source

Test-retest reliability of fMRI brain activity during memory-encoding

open access: yesFrontiers in Psychiatry, 2013
The mechanisms underlying hemispheric specialization of memory are not completely understood. Functional magnetic resonance imaging (fMRI) can be used to develop and test models of hemispheric specialization.
David J Brandt   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Laterality-Specific Training Improves Mental Rotation Performance in Young Soccer Players

open access: yesFrontiers in Psychology, 2018
This study investigates the influence of specific soccer training with the non-dominant leg on mental rotation performance of 20 adolescent soccer players between 10 and 11 years of age.
Stefanie Pietsch, Petra Jansen
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Goal scoring in soccer: A polar coordinate analysis of motor skills used by Lionel Messi

open access: yesFrontiers in Psychology, 2016
Soccer research has traditionally focused on technical and tactical aspects of team play, but few studies have analyzed motor skills in individual actions, such as goal scoring.
Marta eCastañer   +5 more
doaj   +1 more source

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