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Dysregulation of Brain Cholesterol Biosynthetic Pathway following Hypoxia Ischemia in Neonatal Mice.
Dev NeurosciLu F +8 more
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Lathosterol side chain amides—A new class of human lathosterol oxidase inhibitors
Steroids, 2008Inhibition of cholesterol biosynthesis offers the opportunity for treatment of cardiovascular diseases. Numerous enzymes are involved in the post-squalene part of this biosynthesis, and selective inhibitors for almost all of the enzymes involved there have been described in literature. The only exception is the enzyme lathosterol oxidase (EC 1.14.21.6),
Martin A Giera, Franz Bracher
exaly +3 more sources
Clinica Chimica Acta, 1993
Serum levels of cholesterol and the cholesterol precursor lathosterol were determined in five healthy volunteers who took 20 mg simvastatin daily during 1 week. During this period and for the following 5 days blood samples were collected. Five days after ingestion of simvastatin, serum lathosterol had already reached a steady-state level and its ...
De Cuyper, I +3 more
exaly +4 more sources
Serum levels of cholesterol and the cholesterol precursor lathosterol were determined in five healthy volunteers who took 20 mg simvastatin daily during 1 week. During this period and for the following 5 days blood samples were collected. Five days after ingestion of simvastatin, serum lathosterol had already reached a steady-state level and its ...
De Cuyper, I +3 more
exaly +4 more sources
Plasma Lathosterol and Campesterol in Detection of Ileal Dysfunction
Scandinavian Journal of Gastroenterology, 1988Plasma lathosterol levels reflect cholesterol synthesis, especially that induced by bile acid malabsorption, whereas plasma plant sterol contents change in parallel with cholesterol and fat absorption. The significance of lathosterols and plant sterols (campesterol and sitosterol) was therefore studied in detection of ileal dysfunction in 29 patients ...
M A, Färkkilä, T A, Miettinen
exaly +3 more sources
Serum plant sterols and lathosterol related to cholesterol absorption in coeliac disease
Clinica Chimica Acta, 1988The concentrations of the plant sterols, campesterol and beta-sitosterol in serum, normally correlate with the efficiency of cholesterol absorption, whereas the concentration of lathosterol, a cholesterol precursor sterol, closely parallels changes in cholesterol synthesis.
M, Vuoristo, R, Tilvis, T A, Miettinen
exaly +3 more sources
Scandinavian Journal of Gastroenterology, 1988
The human bile contains several noncholesterol sterols, of which the cholesterol precursor sterols are quantitatively the most important. Detailed data on factors that regulate the amount of these sterols in the bile have not been available. In this study the effect of chronic stimulation of cholesterol synthesis on biliary cholesterol precursor sterol
P V, Koivisto, T A, Miettinen
exaly +3 more sources
The human bile contains several noncholesterol sterols, of which the cholesterol precursor sterols are quantitatively the most important. Detailed data on factors that regulate the amount of these sterols in the bile have not been available. In this study the effect of chronic stimulation of cholesterol synthesis on biliary cholesterol precursor sterol
P V, Koivisto, T A, Miettinen
exaly +3 more sources
Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry
Scandinavian Journal of Clinical and Laboratory Investigation, 1989The synthesis of 2H3-labelled lathosterol is described. This compound was used together with 2H7-labelled cholesterol for simultaneous assay of unesterified lathosterol and cholesterol in serum by isotope dilution-mass spectrometry. After addition of a fixed amount of the two internal standards to a fixed amount of serum (in general 25 microliter), the
Ingemar Björkhem
exaly +3 more sources