Results 71 to 80 of about 317,689 (290)

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Assessing the motivational effects of ethanol in mice using a discrete-trial current-intensity intracranial self-stimulation procedure. [PDF]

, 2020
BackgroundAlcohol (ethanol) produces both rewarding and aversive effects, and sensitivity to these effects is associated with risk for an alcohol use disorder (AUD).
Barkley-Levenson, Amanda M, Der-Avakian, Andre, Palmer, Abraham A   +2 more
core  

Development of Raman Spectroscopy and Machine Learning Methods for Protein Aggregate Quantification: Application to BSA in Chromatographic Processes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein aggregation poses a significant risk to biopharmaceutical product quality, as even minor amounts of oligomeric species can compromise efficacy and safety. Rapid and reliable detection of protein aggregates thus remains a major challenge in biopharmaceutical manufacturing.
Jakob Heyer‐Müller, Robin Schiemer, Lars Robbel, Michael Schmitt, Jürgen Hubbuch   +4 more
wiley   +1 more source

On the connection between mutually unbiased bases and orthogonal Latin squares

, 2009
We offer a piece of evidence that the problems of finding the number of mutually unbiased bases (MUB) and mutually orthogonal Latin squares (MOLS) might not be equivalent.
Bengtsson I, Boykin P O Sitharam M Tiep P H Wocjan P, Euler L, Grassl M, Ivanović I D, Klappenecker A, M Grassl, M Pawłowski, Saniga M, T Paterek, Tarry G, Wocjan P, Zauner G, Č Brukner   +13 more
core   +1 more source

The evidence base for ranger patrol effectiveness in conservation and how to improve it

Biological Reviews, EarlyView.
ABSTRACT Ranger patrols are a cornerstone of wildlife protection efforts around the world and occur across all ecological governance systems. Evidence that patrols reduce threats to wildlife and enable their recovery has not been systematically examined previously.
Trina Rytwinski, Robert S. A. Pickles, Matthew J. Muir, Steven J. Cooke, Joseph R. Bennett, Lisa A. Kelly, Adrienne Smith, Cynthia Cadet, Dwi N. Adhiasto, Inés Arroyo Quiroz, Mark D. Booton, Daphne P. Carlson, Drew T. Cronin, Anthony Dancer, Meredith L. Gore, Jennifer R. B. Miller, Stephen F. Pires, Amy Pokempner, James Slade, Andrew M. Lemieux   +19 more
wiley   +1 more source

Applications of design theory for the constructions of MDS matrices for lightweight cryptography

Journal of Mathematical Cryptology, 2017
In this paper, we observe simple yet subtle interconnections among design theory, coding theory and cryptography. Maximum distance separable (MDS) matrices have applications not only in coding theory but are also of great importance in the design of ...
Gupta Kishan Chand, Pandey Sumit Kumar, Ray Indranil Ghosh   +2 more
doaj   +1 more source

Design and analysis of computer experiments using polynomial regression and Latin hypercube sampling in optimal design of PID controller

Journal of Applied Research on Industrial Engineering, 2018
Computational complexity and time-consuming iteration of simulation for tuning of Proportional-Integral-Derivative (PID) controller is a common drawback in many types of existing methods.
Amir Parnianifard , Siti Azfanizam Ahmad, Mohd Khairol Anuar Ariffin, Mohd Idris Shah Ismail   +3 more
doaj   +1 more source

Local-search techniques for propositional logic extended with cardinality constraints

, 2003
We study local-search satisfiability solvers for propositional logic extended with cardinality atoms, that is, expressions that provide explicit ways to model constraints on cardinalities of sets. Adding cardinality atoms to the language of propositional
Liu, Lengning, Truszczynski, Miroslaw
core   +3 more sources

Beyond Profit: Do Mergers and Acquisitions and the Board of Directors Increase the Environmental, Social, and Governance?

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines the relationship between mergers and acquisitions (M&A), board characteristics, and ESG performance in BRICS companies, considering the moderating role of sectoral sensitivity. The study analyzes 11,402 observations from 2293 BRICS companies, employing Two‐Stage Least Squares (2SLS) to address endogeneity and logistic ...
Geovane Camilo dos Santos, Camila Lima Bazani, Pablo Zambra   +2 more
wiley   +1 more source

Intercalates and Discrepancy in Random Latin Squares

, 2017
An intercalate in a Latin square is a $2\times2$ Latin subsquare. Let $N$ be the number of intercalates in a uniformly random $n\times n$ Latin square.
Bartlett, Browning, Brégman, Cameron, Cavenagh, Egorychev, Erdős, Falikman, Heinrich, Häggkvist, Jacobson, Janson, Keedwell, Kotzig, Kotzig, Krivelevich, Kwan, Liebenau, Linial, McKay, McLeish, Ordentlich, Pittenger   +22 more
core   +1 more source