Results 231 to 240 of about 133,347 (349)

First‐in‐class inhibitors of SbnA reduce siderophore production in Staphylococcus aureus

open access: yesThe FEBS Journal, EarlyView.
The production of the iron‐chelating compound staphyloferrin B by the most invasive S. aureus strains is crucial for colonization, virulence, and survival in the host. Staphyloferrin B biosynthesis is carried out by eight enzymes, the Sbn system, that offer an appealing source of potential targets for the development of antimicrobials.
Sarah Hijazi   +15 more
wiley   +1 more source

Structural and functional insights into extreme thermal stability and activity of two GH12 domains of a multidomain glycosidase from a hyperthermophilic euryarchaeon

open access: yesThe FEBS Journal, EarlyView.
The multidomain glycosidase MDG from the hyperthermophilic euryarchaeon Thermococcus sp. contains five protein domains: three catalytic domains (GH5, GH12‐1, and GH12‐2) and two cellulose‐binding modules (CBM2). In this study, the GH12‐1 and GH12‐2 domains were individually purified and biochemically characterized.
Kseniya S. Zayulina   +11 more
wiley   +1 more source

Anions and citrate inhibit LsAA9A, a lytic polysaccharide monooxygenase (LPMO)

open access: yesThe FEBS Journal, EarlyView.
The fungal lytic polysaccharide monooxygenase LsAA9A binds chloride in its crystallization mother liquor, leading to LsAA9A inhibition. Other halides except for fluoride inhibit LsAA9A activity at high concentrations. Transferring crystals to a different solution with lower ionic strength leads to binding of citrate buffer, leading also to the ...
Valerio Di Domenico   +6 more
wiley   +1 more source

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