Results 61 to 70 of about 1,045,314 (288)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

Online Operation Modal Identification for Machining Robot Based on Optimized SSI Method

open access: yesApplied Sciences
To improve the machining ability of serial robots, an optimized SSI method is proposed to realize online modal identification. Firstly, the method employs the NExT technology, modal confidence factor, and modal assurance criterion to improve the ...
Hui Guo   +3 more
doaj   +1 more source

A boundary layer transition criteria on three-dimensional flow for high-speed aircraft [PDF]

open access: yesAIP Advances
Boundary layer transition of high-Mach vehicles, which could greatly affect the vehicle’s aerodynamic performance and thermal characteristics, is an inevitable flow phenomenon during flight.
Hao Yan, Guang Yang, Tong Huang
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

A Delay-Aware Switching Framework for Binary Actuator Systems Under Sensing Delay and Measurement Noise

open access: yesSensors
Binary actuator systems are widely used in industrial and agricultural automation because of their simple structure and low implementation cost. However, sensing delay and measurement noise can cause repeated triggering when threshold conditions are ...
Kiman Ji
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Pathways to Aerodynamic Innovation Breakthroughs: Perspectives from Engineering Practice

open access: yes气体物理
To meet the engineering demands of cross-domain high-speed vehicles operating across wider airspace and speed ranges, aerodynamics is evolving with trends characterized by extreme macro- and micro-scales, extreme environmental conditions, and highly ...
Guangsheng ZHU   +4 more
doaj   +1 more source

Launch Vehicles of ISAS [PDF]

open access: yesInternational Astronomical Union Colloquium, 1990
AbstractThe Institute of Space and Astronautical Science (ISAS) has developed a series of launch vehicles for delivering modest scale scientific satellites into space. This capability is unique for an inter-university research institute. The present ISAS launch vehicle, M-3S II, carries a 770 kg payload into a low earth orbit (LEO).
openaire   +1 more source

More Than a Wing and a Prayer: Government Indemnification of the Commercial Space Launch Industry [PDF]

open access: yes
Using rockets to launch communications satellites and other spacecraft poses risks to the uninvolved public, including persons and property under the flight path of the launch vehicle.
Macauley, Molly K.   +2 more
core   +2 more sources

Vented Launch Vehicle Adaptor for a Manned Spacecraft with "Pusher" Launch Abort System [PDF]

open access: yes, 2017
A system, method, and apparatus for a vented launch vehicle adaptor (LVA) for a manned spacecraft with a "pusher" launch abort system are disclosed. The disclosed LVA provides a structural interface between a commercial crew vehicle (CCV) crew module ...
Vandervort, Robert E.
core  

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