Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
交大法學評論, 2022 選任程序是一般國民要成為國民法官所需歷經的重要程序，但全國各地由司法院舉辦之模擬審判中，針對選任程序的操作方法產生許多疑問。本文參考美國陪審制之實務運作以及相關之社會科學研究，認為選任程序的關鍵在於排除偏見以促進公平審判，以及透過程序正義促進信賴。欲達成排除偏見的目的，必須針對候選國民法官取得足夠的資訊，而欲促進信賴，則必須兼顧程序參與。是以，本文建議應於審前擴大使用書面問卷，並在選任程序時，以書面問卷的內容為基礎，將多數時間使用於兩造主導之個別詢問，並同時利用全體詢問兼顧其餘候選陪審員之程序參與 ...
金孟華 Mong-Hwa Chin
doaj
Introduction: food relocalisation and knowledge dynamics for sustainability in rural areas [PDF]
, 2010 The chapter presents the literature on local food and local knowledge and introduces the case studies analysed in the ...
FONTE, MARIA CATERINA
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
What Discourages Participation in the Lay Judge System (Saiban’in Seido) of Japan? Interaction between the Secrecy Requirement and Social Networks. [PDF]
The lay judge system, a quasi-jury system, was introduced in Japan from May 2009. This paper attempts to analyze Japanese people’s attitude towards this system by examining whether they show a willingness to serve as a lay judge.
Yamamura, Eiji
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Citizens’ Participation Using Sortition: A practical guide to using random selection to guarantee diverse democratic participation [PDF]
, 2018 Sortition is part of our everyday lives. If a deci- sion is to be unbiased and incorruptible as well as guarantee absolute equality of opportunity, it is often decided by random selection.
Vergne, Antoine
core