Results 151 to 160 of about 128,206 (299)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Byzantine Lay Piety, ca. 600-730
, 2014 The present study addresses lay piety in Byzantium from the perspective of its relation to the monastic ideal. My approach builds on work such as Peter Brown's analysis of early Christian asceticism, The Body and Society and John Haldon's socio-cultural ...
Marinides, Nicholas George
core
Plain Language Summarization of Environmental Health Research Using Generative AI: Community-Engaged Qualitative Study. [PDF]
J Med Internet ResWade K, Anderson LB, Medley EM, Smith T.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2019 This thesis approaches dietary guidance as socio-culturally produced and comprised in a specific historical context. The work is premised on the position that ideas and understandings of healthy eating are discursively constructed, and that we form our ...
Bergman, Karolin
core
Does graft thickness affect outcomes in massive rotator cuff repairs with on-lay and bridging graft augmentation? A systematic review and meta-analysis. [PDF]
Shoulder ElbowSain B +4 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Equity Academy Looking Forward Lay Summary in English
Lay summary in English of looking forward to bridging infrastructures for equitable COVID-19 testing and ...
openaire +1 more source