Results 211 to 220 of about 936,967 (303)

Developmental Stage-Specific Responses to Extreme Climatic Events and Environmental Variability in Great Tit Nestlings. [PDF]

Glob Chang Biol
Satarkar D, López-Idiáquez D, Sepil I, Sheldon BC.   +3 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A rapid evaluation of the reporting and publishing practices of patient and public involvement and engagement in health research within a UK university institute. [PDF]

Res Involv Engagem
Scott HM, Price L, Ogden M, Bharadia T, Burke P, Horne R, Harding-Bell A, Tonkin A, Thomson A.   +8 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A protocol for an emergency front-of-neck airway registry in the United Kingdom. [PDF]

BJA Open
Ghosh P, McNarry AF, Cook T, Jimbu N, Cortés L, El-Boghdadly K, Ahmad I, Taylor C, Moppett IK.   +8 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Applying human-centered design to adapt a multifaceted implementation strategy for integrating HIV and NCD services in Lusaka, Zambia: Healthcare worker perspectives. [PDF]

PLOS Glob Public Health
Matenga TFL, Herce ME, Corbin JH, Zulu JM, Mwila C, Mandyata C, Frimpong C, Siame M, Shankalala P, Nachalwe N, Mbewe P, Chisenga P, Sichone P, Musheke M, Mutale W, Mweemba O.   +15 more
europepmc   +1 more source

Should I lie? Approaches to dementia care - Lay Summary

This all Ireland study found that that existing ethical and practice codes say it is never acceptable to lie to patients in any circumstances. However, the research found that the use of therapeutic lying is, in certain circumstances, considered an acceptable strategy by health professionals, informal/unpaid carers and people with dementia themselves ...
openaire   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Navigating market access after conditional reimbursement: a communication roadmap for disinvesting orphan drugs. [PDF]

Int J Technol Assess Health Care
Abdallah K, Blonda A, Godman B, Huys I, Claes K, Denier Y, Simoens S.   +6 more
europepmc   +1 more source