Results 71 to 80 of about 128,206 (299)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Co-producing public involvement training with members of the public and research organisations in the East Midlands: creating, delivering and evaluating the lay assessor training programme

Research Involvement and Engagement, 2017
Plain english summary Members of the public share their views with researchers to improve health and social care research. Lay assessing is one way of doing this.
Adele Horobin, George Brown, Fred Higton, Stevie Vanhegan, Andrew Wragg, Paula Wray, Dawn-Marie Walker   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Lay Summary in Medical Research Proposals - is it becoming more important?

, 2010
One of the skills every researcher must learn is how to present complex ideas and medical or scientific terms to a “lay” audience, for example members of the public, carers, long-term users of services, organisations representing consumers’ interests ...
Ashmore, C, Smith, Mark
core  

Changes in symptom burden and quality of life among women with uterine fibroids receiving relugolix combination therapy: a plain language summary

Journal of Comparative Effectiveness Research
This is a summary of findings from two research studies (known as clinical trials). The studies looked at how well a medicine called relugolix combination therapy worked in women with heavy menstrual bleeding (heavy bleeding during a period) with uterine
Elizabeth A Stewart, Andrea S Lukes, Roberta Venturella, Yulan Li, Elke Hunsche, Rachel B Wagman, Ayman Al-Hendy   +6 more
doaj   +1 more source

Artificial insemination and laying cycle influence adaptive immune cell numbers and localization in the reproductive tract of turkey breeder hens

Poultry Science
Weekly artificial insemination (AI) is a common practice on commercial turkey breeder farms. The aim of this study was to determine changes in stress as well as oviduct and systemic immunity in response to weekly artificial inseminations through the ...
Yifan Chen, Sunantha Kosonsiriluk, Lillian X. Ehresmann, Kent M. Reed, Sally L. Noll, Ben W. Wileman, Marissa M. Studniski, Kahina S. Boukherroub   +7 more
doaj   +1 more source

ARTIFICIAL INTELLIGENCE AND ROBOTICS: CONTRIBUTIONS FROM THE SCIENCE AND RELIGION FORUM

Zygon, 2020
The Science and Religion Forum (SRF) seeks to be the premier organization promoting the discussion between science and religion in the United Kingdom for academics, professionals, and interested lay people. Each year, the SRF holds a conference tackling
doaj   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improvements in daytime sleepiness and disrupted nighttime sleep with once-nightly sodium oxybate in people with narcolepsy type 1 and type 2: a plain language summary

Journal of Comparative Effectiveness Research
What is this summary about? This is a plain language summary of a published article in the journal Sleep. Narcolepsy is a sleep condition that has 2 different subtypes: narcolepsy type 1 and narcolepsy type 2. These are called NT1 and NT2 for short.
Yves Dauvilliers, Thomas Roth, Richard Bogan, Michael J Thorpy, Anne Marie Morse, Fèri Ascencion, Jennifer Gudeman   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source