Results 151 to 160 of about 58,089,599 (262)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Layer-by-layer shear densification for multiscale hierarchical alignment in bulk hydrogels. [PDF]

Nat Commun
Wang S, Tang S, Fu T, Jiang Y, Lin Y, Fu L, Wu R, Lin Y.   +7 more
europepmc   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Layer-by-layer polymer coating on discrete particles of cubic lyotropic liquid crystalline dispersions (cubosomes)

, 2013
Cubic phase lyotropic liquid crystalline colloidal dispersions (cubosomes) were surface-modified with seven polyelectrolyte layers using a layer-by-layer (LbL) approach.
X Mulet (13468413), H Thissen (9976664), Lynne Waddington (1495762), Almar Postma (1278660), Frank Caruso (1269705), C.D. Driever (20017464), Calum Drummond (18026164)   +6 more
core  

Microstructures and growth characteristics of polyelectrolytes on silicon using layer-by-layer assembly

Open Chemistry, 2013
Bragaru Adina, Kusko Mihaela, Radoi Antonio, Danila Mihai, Simion Monica, Craciunoiu Florea, Pascu Razvan, Mihalache Iuliana, Ignat Teodora   +8 more
doaj   +1 more source

"Single-Cell Encapsulation of Lactiplantibacillus Plantarum Via Layer-by-Layer Technique for Enhanced Viability and Shelf Life: Insights on Multilayer Assembly on Bacteria". [PDF]

Macromol Biosci
Chotechuang N, Nayem MF, Gianvincenzo PD, Manowan P, Gutiérrez-Pineda E, Arnaiz B, Llarena I, Abarrategi A, Puangpaka A, Boonla C, Moya SE.   +10 more
europepmc   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Layer-by-layer deposition of polyelectrolyte assemblies on crop seeds as a platform for active ingredient loading and controlled release. [PDF]

RSC Adv
Rudich K, Tani S, Aleem A, Choi Y, Voronov A, Quadir M.   +5 more
europepmc   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Surface Reordering During Layer-by-Layer Growth on SrTiO₃. [PDF]

Adv Mater
Tung IC, Yan X, Lee JH, Liu Y, Chang SH, Luo Z, Wrobel F, Cheung NT, Lopez KR, Bedzyk MJ, Hong H, Freeland JW, Zhou H, Letchworth-Weaver K, Fong DD.   +14 more
europepmc   +1 more source