Results 111 to 120 of about 58,086,707 (305)

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Nature Communications
80 pages, 33 figures; v2 substantial changes to improve ...
Dominic J. Williamson, Nouédyn Baspin
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nonlinear disturbance evolution in a two-dimensional boundary layer along an elastic plate and induced radiated sound [PDF]

, 2010
The interaction between a boundary-layer flow and an elastic plate is addressed by direct numerical simulation, taking into account the full coupling between the fluid flow and the flexible wall.
EHRENSTEIN, Uwe, BOT, Patrick, GOBERT, Marie-Laure, Astolfi, André, Astolfi, Jacques-André, ASTOLFI, Jacques Andre   +5 more
core   +1 more source

Layers of Looking

i-Perception, 2011
The films that I make are part documentary, part film essay, part visual poem. They are created out of a series of up to 30 drawings that are animated. The process from research to completion takes about 2 years, and at the end of it there is a film and a number of drawings that can be exhibited.
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Layer-by-layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment

, 2012
Layer-by-layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility ...
Yan Zhao (13100625), Hong Wang (13073637), Tong Lin (13098042), Yanwei Tang (13051476), Yuan Gao (13049700), Xungai Wang (13100496), Xin Liu (13100436)   +6 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

LAYER-BY-LAYER NANOSCALE BONDLINES FOR MACROSCALE ADHESION

BioResources, 2010
The objective of this study was to test the bonding performance of nanoscale bondlines, which were fabricated with polyelectrolytes by layer-by-layer assembly process onto wooden substrates. In this study, environmental scanning electron microscopy (ESEM)
Yu Zhou, Scott Renneckar, Qingqing Li, Karthik V Pillai, Zhiyuan Lin, W Travis Church   +5 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Layer-by-Layer Nanoparticles for Calcium Overload in situ Enhanced Reactive Oxygen Oncotherapy

International Journal of Nanomedicine
Boye Zhang,1,2 Jianliang Man,3,4 Lingyun Guo,1 Xiaoxia Ru,1 Chengwu Zhang,1,2 Wen Liu,1,2,5 Lihong Li,1,2,5 Sufang Ma,1,2 Lixia Guo,2,4 Haojiang Wang,1,2 Bin Wang,1,2 Haipeng Diao,1,5 Renchao Che,6,7 Lili Yan1,2,5 1School of Basic Medical Sciences ...
Zhang B, Man J, Guo L, Ru X, Zhang C, Liu W, Li L, Ma S, Guo L, Wang H, Wang B, Diao H, Che R, Yan L   +13 more
doaj