Results 81 to 90 of about 2,555,152 (303)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2016 Colloidal assembly is one of the highly active areas in nanoscale science and technology as it plays an important role in organizing nanoscale building blocks into hierarchical and functional systems for practical applications.
Guihua Yu (1440559) +4 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Uncovering the Galloway Viking Hoard, layer by layer
, 2017 Hold on to your Viking helmet; you’re about to dig, layer by layer, into one of the most extraordinary Viking hoards ever found on the British Isles – the Galloway Hoard – with Dr Martin Goldberg, Senior Curator at National Museums ...
Goldberg, D Martin
core
, 2016 Water-soluble poly(ferrocenylsilane) (PFS) and poly(styrenesulfonate) (PSS) of alternating charge are shown to self-assemble in a layer-by-layer fashion on primed Au, Si, and quartz substrates to create the first examples of organic−organometallic ...
K. Nicole Power-Billard (3055254) +9 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Pharmaceuticals, 2018 Currently, one of the greatest health challenges worldwide is the resistance to antibiotic drugs, which has led to the pursuit of new alternatives for the recovery of biological activity, where the use of different types of nano-systems has shown an ...
Lina M. Arévalo +3 more
doaj +1 more source
The onset of instability in unsteady boundary-layer separation
, 1996 The process of unsteady two-dimensional boundary-layer separation at high Reynolds number is considered. Solutions of the unsteady non-interactive boundary-layer equations are known to develop a generic separation singularity in regions where the ...
K. W. Cassel +5 more
core +1 more source