Results 221 to 230 of about 4,297,894 (335)

Mechanism and application of competitive fracture propagation in layered group fracturing of massive thick overburden strata. [PDF]

Sci Rep
Zhang X, Cao Y, Gou Y, Wen S, Huang N, Cho Y.   +5 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Ruddlesden-Popper chalcogenides push the limit of mechanical stiffness and glass-like thermal conductivity in single crystals. [PDF]

Nat Commun
Hoque MSB, Hoglund ER, Zhao B, Bao DL, Zhou H, Thakur S, Osei-Agyemang E, Hattar K, Scott EA, Surendran M, Tomko JA, Gaskins JT, Aryana K, Makarem S, Alwen A, Hodge AM, Balasubramanian G, Giri A, Feng T, Hachtel JA, Ravichandran J, Pantelides ST, Hopkins PE.   +22 more
europepmc   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source

The Role of Intergranular Cracks on Fast Charging and Accelerated Degradation in Polycrystalline Layered Oxide Cathodes. [PDF]

Adv Sci (Weinh)
Min J, Glossmann T, Li Y.
europepmc   +1 more source

Mitigating the Rock‐Salt Phase Transformation in Disordered LNMO Through Synergetic Solid‐State AlF3/LiF Modifications

Advanced Science, EarlyView.
The transition between the spinel and rock‐salt phases induces irreversible structural changes in disordered LiNi0.5Mn1.5O4, thereby preventing it from fully releasing its electrochemical capacity during charge/discharge cycling. Abstract High‐voltage disordered spinel LiNi0.5Mn1.5O4 is a promising cathode material for high power density in lithium‐ion
Xingqi Chang, Carlos Escudero, Ashley P Black, Sharona Horta, Elías Martínez, Xuan Lu, Jordi Llorca, Maria Ibáñez, Jordi Jacas Biendicho, Andreu Cabot   +9 more
wiley   +1 more source

Identification of Laminar Structure in the Yingxiongling Shale Oil Sediment in China with Random Forests and SHAP Analysis. [PDF]

ACS Omega
Zhang F, Liu X, Aldrich C, Deng S, Li G.
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Effect of High-Multiple Water Flooding and Layered Allocation on Oil Displacement Efficiency in Unconsolidated Sandstone Reservoirs. [PDF]

ACS Omega
Jin L, Deng J, Liang J, Liu L, Zhang X, Lu H, Yang T, Tang H.   +7 more
europepmc   +1 more source