Results 141 to 150 of about 4,217,928 (269)

Rock breaking regularity of layered rock mass blasting under the influence of different resistance lines

open access: yesMeitan kexue jishu
Layered rock is a common geological structure of underground engineering construction, drilling and blasting method construction in layered rock is manifested in poor blasting and shaping effect, serious phenomenon of over and under excavation, uneven vibration propagation and other problems.
Jianxin YU   +3 more
openaire   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

open access: yesAdvanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing   +9 more
wiley   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

open access: yesAdvanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping   +4 more
wiley   +1 more source

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

open access: yesAdvanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang   +11 more
wiley   +1 more source

Study on the Stability of Rock Walls in Shallow-Buried Tunnels with Small Clearances in Layered Rock Masses

open access: yes
AbstractIn the engineering of tunnels with small clearances, the structural features of rock layers play a crucial role in the stability of the central rock walls. This study employed the Discrete Element Method software (UDEC) to simulate the mechanical response of tunnels with small clearances under various rock layer dip angles, both in unfortified ...
openaire   +1 more source

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

open access: yesAdvanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng   +8 more
wiley   +1 more source

When are Two‐Dimensional Covalent Organic Frameworks Good Electrodes for Lithium Ion Batteries? A Data‐Driven Analysis

open access: yesAdvanced Science, EarlyView.
A data‐driven framework integrating density‐functional theory with machine learning models screens two‐dimensional covalent organic frameworks (2D COFs) from CoRE COF database to reveal atomic‐level design rules: N/O‐rich coordination pockets drive cathode behavior, while separated redox sites and π‐rich galleries enable anode function in Li‐ion ...
Preeti Bhauriyal   +2 more
wiley   +1 more source

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