A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
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AbstractThe problems of layout of printed circuits and large scale integrated chips are very complex and are therefore usually approached by heuristic methods.This paper presents a more analytic approach to an elementary subset of these problems, using combinatorial and graphtheoretic arguments.
M. Cutler, Yossi Shiloach
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