Results 41 to 50 of about 1,363,311 (344)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Exploring Local Optima in Schematic Layout [PDF]

open access: yes, 2013
In search-based graph drawing methods there are typically a number of parameters that control the search algorithm. These parameters do not affect the ?tness function, but nevertheless have an impact on the ?nal layout. One such search method is hill
Chivers, Daniel, Rodgers, Peter
core  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging

open access: yesBMC Complementary and Alternative Medicine, 2018
Background Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages.
Induja Kalyana Sundaram   +4 more
doaj   +1 more source

Ariel - Volume 12(13) Number 2 [PDF]

open access: yes, 1983
Editor Gary Fishbein Production & Business Manager Rich Davis Layout Editor Lynn Solomon Assistant Layout Editors Bessann Dawson Tonie Kline Becky A.
Brucker, Paul C.   +9 more
core   +1 more source

Multidimensional Pareto optimization of touchscreen keyboards for speed, familiarity and improved spell checking [PDF]

open access: yes, 2012
The paper presents a new optimization technique for keyboard layouts based on Pareto front optimization. We used this multifactorial technique to create two new touchscreen phone keyboard layouts based on three design metrics: minimizing finger travel ...
Dunlop, Mark, Levine, John
core   +2 more sources

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

open access: yesFEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó   +7 more
wiley   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

open access: yesAdvanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez   +8 more
wiley   +1 more source

PERANCANGAN ULANG TATA LETAK FASILITAS PRODUKSI DENGAN METODE GRAFIK DAN METODE CRAFT DI UD. PRIMADONA

open access: yesAgrointek, 2021
UD. Primadona is a company that sells typical Jember snacks. At the moment, the condition of the facility layout of UD. Primadona faced many problems. One of them is a distinctive design that there is a long flow of material transfer.
nita kuswardhani, Bertung Suryadharma
doaj   +1 more source

On Linear Layouts of Graphs [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2004
In a total order of the vertices of a graph, two edges with no endpoint in common can be \emphcrossing, \emphnested, or \emphdisjoint. A \emphk-stack (respectively, \emphk-queue, \emphk-arch) \emphlayout of a graph consists of a total order of the vertices, and a partition of the edges into k sets of pairwise non-crossing (non-nested, non-disjoint ...
Dujmović, Vida, Wood, David R.
openaire   +5 more sources

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