Results 41 to 50 of about 155,700 (212)
Tunable Multifunctional Terahertz Coding Metasurface for Polarization Manipulation
Advanced Photonics Research, EarlyView.Coding metasurfaces (CMs) offer versatile control over electromagnetic waves. Herein, a tunable multifunctional terahertz (THz) metasurface integrated with vanadium dioxide (VO2) is presented, enabling propagation‐phase manipulation of linearly polarized waves and hybrid‐phase control of circularly polarized waves.
Chunsheng Zhang +10 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects
Advanced Science, EarlyView.The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su +14 more
wiley +1 more source
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik +13 more
wiley +1 more source
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
The Effects of JIT on the Development of Productivity Norms [PDF]
, 1997 Low inventory, or just-in-time (JIT) manufacturing systems, enjoy increasing application worldwide, yet the behavioral effects of such systems remain largely unexplored.
Boudreau, John W. +2 more
core +1 more source
Advanced Science, EarlyView.Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong +12 more
wiley +1 more source
Advanced Science, EarlyView.During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen +10 more
wiley +1 more source
Beauty and the Beastly Prime Minister [PDF]
, 2014 This essay examines the so-called “turn to beauty” in British fiction since the 1990s as a response to the political and social consequences of Thatcherism. Focusing primarily on four texts—Jonathan Coe’s What a Carve Up! (1994), Julian Barnes’s England,
Su, John J.
core +1 more source
Advanced Science, EarlyView.High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos +12 more
wiley +1 more source