Results 41 to 50 of about 1,886 (209)

Short‐Course Low‐Dose Primaquine for Radical Cure in G6PD‐Normal Patients in the Pre‐Elimination Context of Nepal

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background Plasmodium vivax remains a challenge for malaria elimination in Nepal due to its ability to relapse. Radical cure with primaquine is effective but limited by poor adherence to the standard 14‐day low‐dose regimen. In 2022, the WHO recommended administering the same total dose (3.5 mg/kg) over 7 days to improve adherence.
Prakash Ghimire, Gokarna Dahal, Nabaraj Adhikari, Komal Raj Rijal, Sanjib Adhikari, Megha Raj Banjara, Hellen Mnjala, Grant Lee, Sophie Weston, Angela Rumaseb, Anjana Rai, Benedikt Ley, Mohammad Sharif Hossain, Julie A. Simpson, Megha Rajasekhar, Bipin Adhikari, Ric N. Price, Bibek K. Lal, Kamala Thriemer   +18 more
wiley   +1 more source

Visualization of supercritical water pseudo-boiling at Widom line crossover

Nature Communications, 2019
Supercritical water exists in gas- and liquid-like forms, but these have not been distinguished yet at the macroscale. Here the authors investigate supercritical water interacting with microporous carbon by neutron imaging, and observe the coexistence of
Florentina Maxim, Cristian Contescu, Pierre Boillat, Bojan Niceno, Konstantinos Karalis, Andrea Testino, Christian Ludwig   +6 more
doaj   +1 more source

Modelling the Neolithic dispersal in northern Eurasia

Documenta Praehistorica, 2004
Comprehensieve lists of radiocarbon dates from key Early Neolithic sites in Central Europe belonging to the Linear pottery Ceramic Culture (LBK) and early pottery-bearing cultures in the East European Plain were analysed with the use of the x2 test.
Pavel Dolukhanov, Anvar Shrukov
doaj   +1 more source

High Soluble Tumor Necrosis Factor Receptor 2 in Serum Is Associated With Inferior Overall Survival Across Major Lymphoma Subtypes

American Journal of Hematology, Volume 101, Issue 6, Page 1388-1397, June 2026.
ABSTRACT Soluble tumor necrosis factor receptor 2 (sTNFR2) is a member of the TNF superfamily whose normal bodily distribution is largely limited to low level expression on lymphoid cells. It has emerged as an important inducible receptor that activates a signaling pathway for cancer growth.
Arushi Khurana, Hikaru Hayashi, Bethany Thach, Zhi Zhang Yang, Brianna J. Negaard, James R. Cerhan, Anne J. Novak, Brian K. Link, Thomas M. Habermann, Andrew L. Feldman, Sameer A. Parikh, Susan L. Slager, Stephen M. Ansell, Matthew J. Maurer, Denise L. Faustman   +14 more
wiley   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Do Medication Beliefs Influence Adherence to Topical Therapies in Patients With Atopic Dermatitis?

JEADV Clinical Practice, Volume 5, Issue 2, Page 558-570, June 2026.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 10–20% of the global population and is characterized by red, itchy, and dry skin. While consistent medication adherence is necessary for adequate management of AD, patients' adherence to topical therapies can decline by 70% within initial days of treatment ...
Vivien Wen Ting Tai, Luke Jun Jie Oh, Yik Weng Yew, Benny Kaihui Li   +3 more
wiley   +1 more source

Investigating enablers and barriers to home enteral nutrition care and blended tube feeding use in adult clients: A mixed methods study

Nutrition &Dietetics, Volume 83, Issue 3, Page 355-368, June 2026.
Abstract Aim To investigate enablers and barriers to providing home enteral nutrition care and the use of blended tube feeding for adult clients. Methods An explanatory sequential mixed‐methods study mapped to the Theoretical Domains Framework, comprising a national cross‐sectional web‐based survey, descriptive qualitative analysis of focus groups, and
Lina Breik, Janet Golder, Lisa A. Barker, Judy Bauer, Zoe E. Davidson   +4 more
wiley   +1 more source

Circulating levels of insulin‐like growth factor I (IGF‐I) and risk of multiple myeloma: An observational and Mendelian randomisation study

British Journal of Haematology, Volume 208, Issue 6, Page 1942-1953, June 2026.
Summary Evidence for an association between insulin‐like growth factors (IGF) and multiple myeloma (MM) is inconsistent. We examined total IGF‐I concentrations and risk of MM by combining baseline serological data among UK Biobank participants (n = 444 187; 732 incident MM) with a two‐sample Mendelian randomisation (MR) analysis using identified ...
Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa Clay‐Gilmour, Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qing Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Shaji K. Kumar, Celine M. Vachon, Anne J. Novak, Thomas M. Habermann, Brian K. Link, Gilles Salles, Herve Ghesquieres, Paige M. Bracci, Elizabeth Holly, Rosalie G. Griffin, Michelle A. T. Hildebrandt, Roel C. H. Vermeulen, P. Martijn Kolijn, Henrik Hjalgrim, Karin Ekström Smedby, Harindra Jayasekara, Simon Cheah, Alain Monnereau, Yu Chen, Alan Arslan, Yawei Zhang, Nicola J. Camp, Douglas W. Sborov, Afaf E. G. Osman, Elad Ziv, Immaculata De Vivo, Vijai Joseph, Lauren R. Teras, Alpa V. Patel, Eleanor Kane, Claire M. Vajdic, Adrien Guilloteau, Pierluigi Cocco, Laia Alemany, Juan Sainz, James McKay, Brenda M. Birmann, Delphine Casabonne   +56 more
wiley   +1 more source

A Refined Method for Fecal Microbiota Transplantation Using Nutella

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Fecal microbiota transplantation (FMT) in mice is an evolving research field, often employing oral gavage, which can be stressful and harmful for the animals and time‐consuming for technicians. Voluntary intake methods, such as delivery in Nutella, have successfully been used for drug administration in mice and may likewise be a promising tool
Ida W. Henriksen, Camilla H. F. Hansen, Janne Koch, Dorte B. Sørensen, Dennis S. Nielsen, Christina Bartholdy, Axel K. Hansen   +6 more
wiley   +1 more source

The Inflammatory Response in the Murine Ovalbumin‐Induced Skin Inflammation Model Is Robust Despite Major Gut Microbiota Differences

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Valid pre‐clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low‐to‐moderate inflammatory responses with significant variability, undermining their validity and contributing to high drug attrition rates.
Ida Wang Henriksen, Christina Bartholdy, Janne Koch, Denitsa Vladimirova Stefanova, Camilla Hartmann Friis Hansen, Axel Kornerup Hansen   +5 more
wiley   +1 more source