Results 201 to 210 of about 69,141 (248)

Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study. [PDF]

Alzheimers Dement
Dugger BN, Luu MN, Patel V, DeCarli C, Jin LW, Gilsanz P, Mungas D, Kawas C, Corrada MM, Whitmer RA.   +9 more
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Caregivers' Preference for Antipsychotic Medication for Youth Less Than 18 Years-Old: A Discrete Choice Experiment Pilot. [PDF]

Patient Prefer Adherence
Fu YH, Bozzi LM, Butler B, dosReis S.
europepmc   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

α-Synuclein in Lewy Body Diseases: Progress, Remaining Challenges and Future Perspectives. [PDF]

Expert Rev Mol Med
Grimwade IJH, Enticknap G, De Pablo Fernandez E, Croft CL.   +3 more
europepmc   +1 more source

Der Elektronischen Lesesaal an der Thüringer Universitäts- und Landesbibliothek Jena: MyBib eRoom der Fa. Imageware

, 2011
Kunze, Petra
core  

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Access to medication: key to achieving treatment goals

Bulletin of the World Health Organization, 2008
Hevertton LBS Santos, Nelson Rosario
doaj  

Impact of congenital anomalies on infant mortality in the 14th Health Region of Paraná, from 2010 to 2019. [PDF]

Rev Paul Pediatr
Muniz NF, Babalola AD, Costa MAR, Schuler-Faccini L.   +3 more
europepmc   +1 more source