Results 121 to 130 of about 23,319 (231)

Tissue‐specific and spatially dependent metabolic signatures perturbed by injury in male and female mice

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis—the leading cause of disability worldwide—disproportionately affects females, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Analysis with LC-OCT imaging in split face with CO₂ laser and 1540 nm. A case report. [PDF]

Oxf Med Case Reports
Moro F, Fusco I, Madeddu F, Ambrosio L, Chello C, Di Lella G, Zingoni T, Colonna L.   +7 more
europepmc   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Noninvasive Imaging Techniques as Modern Diagnostic Tools in Desquamative Gingivitis: Focus on RCM, OCT, and LC-OCT. [PDF]

Skin Res Technol
Fałkowska U, Durmaj A, Szwed C, Kurzeja M, Czuwara J, Olczak-Kowalczyk D, Rudnicka L, Olszewska M.   +7 more
europepmc   +1 more source

Melanocytic Clefting Observed Using LC-OCT

EJC Skin Cancer
M.J. Pérez-Anker, S. Soglia, S. Puig, A. Garcia, R. Albero, B. Alejo, E. Cinotti, C. Orte Cano, C. Habougit, F. Skowron, L. Pellegrino, L. Tognetti, C. Lenoir, P. Castillo, P. Rubegni, M. Suppa, J.L. Perrot, V. Del Marmol, L. Alos, J. Malvehy   +19 more
openaire   +1 more source

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex

Chemistry – A European Journal, EarlyView.
Targeting disease‐linked RNAs with small molecules is often limited by the modest impact of binding RNA structure alone. Here, we present a first‐in‐class bifunctional molecule that degrades the oncogenic lncRNA MALAT‐1 by inducing proximity between the RNA and a cleaving warhead.
Christian A. T. Brega, Benjamin A. Craig, Sigitas Mikutis, Rupert S. J. Proctor, Yuliia Vyborna, Maria Eleftheriou, Kostas Tzelepis, Mo Yang, Shaifaly Parmar, Javier Bonet‐Aleta, John S. Schneekloth Jr., Gonçalo J. L. Bernardes   +11 more
wiley   +1 more source

Maternal‐to‐Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines

Clinical Pharmacology &Therapeutics, EarlyView.
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Katherine Richardson, Joshua Kiptoo, Beatrice Mpora Odongkara, Francis Williams Ojara, Catriona Waitt   +4 more
wiley   +1 more source

Criteria for melanocytic lesions in LC-OCT

EJC Skin Cancer
M.J. Pérez-Anker, S. Soglia, C. Lenoir, R. Albero, L. Alos, A. Garcia, B. Alejo, E. Cinotti, C. Orte Cano, C. Habougit, L. Pellegrino, L. Tognetti, P. Castillo, P. Rubegni, M. Suppa, J.L. Perrot, V. Del Marmol, S. Puig, J. Malvehy   +18 more
openaire   +1 more source

Identification and Structural Elucidation of a New Synthetic Cannabinoid, MDMB‐5′Br‐PINACA, in Seized Herbal Materials

Drug Testing and Analysis, EarlyView.
MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi, Lucas André Zeoly, Rafael Lanaro, Ingrid Simões Oliveira, Mariana Cepollaro Diana, Mauricio Yonamine, Jose Luiz Costa   +6 more
wiley   +1 more source

Diagnostic criteria for melanocytic lesions in LC-OCT

EJC Skin Cancer
M.J. Pérez-Anker, S. Soglia, C. Lenoir, R. Albero, L. Alos, E. Cinotti, L. Pellegrino, L. Tognetti, P. Rubegni, M. Suppa, J.L. Perrot, V. del Marmol, S. Puig, J. Malvehy   +13 more
openaire   +1 more source