Results 221 to 230 of about 38,748 (248)

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.

Journal of Medicinal Chemistry, 2021
Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to their ...
M. Hartmann, J. Huber, J. Kramer, J. Heering, Larissa Pietsch, H. Stark, D. Odadzic, I. Bischoff, R. Fürst, M. Schröder, M. Akutsu, A. Chaikuad, V. Dötsch, S. Knapp, R. Biondi, V. Rogov, E. Proschak   +16 more
semanticscholar   +4 more sources

SETD7 promotes LC3B methylation and degradation in ovarian cancer

Journal of Biological Chemistry
Microtubule-associated protein 1 light chain 3 (LC3) is a key autophagy-related protein involved in regulating autophagosome formation and autophagy activity. Post-translational modifications of LC3 are necessary to modulate its function.
Ziwei Zhang, Mingyang Li, Yanan Hou, Ting Huang, Bowen Zhang, Qiong Lin, Genbao Shao   +6 more
semanticscholar   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

LC3B/p62-mediated mitophagy protects A549 cells from resveratrol-induced apoptosis.

Life Sciences, 2021
AIMS Complicated mechanisms in cancer cells have been restricting the medicinal value of resveratrol (Res). The mechanisms by which Res exerts its anti-tumor activity in lung cancer cells have diverged among reports in recent years, whether cells choose ...
Jiahua Zheng, Shao-chun Wei, T. Xiao, Guanwu Li   +3 more
semanticscholar   +3 more sources

Total Linear Chemical Synthesis of LC3A and LC3B

2022
Solid-phase peptide synthesis (SPPS) enables the synthesis of chemically modified peptides and proteins. Chemically synthesized ubiquitin(-like) proteins containing a fluorescent tag or reactive warhead have proven to be important tools in elucidating biological processes.
Huppelschoten, Yara, Buchardt, Jens, Nielsen, Thomas Eiland, van der Heden van Noort, Gerbrand J.   +3 more
openaire   +2 more sources

Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations.

European journal of medicinal chemistry
Targeted protein degradation through autophagosome-tethering compounds (ATTECs) that bypasses the ubiquitination process has garnered increasing attention.
Yanping Zeng, Jian Xiao, Lili Shi, Yangsha Li, Yuanxin Xu, Jiayun Zhou, Xiao Dong, Haiyang Hou, Chao Zhong, Gang Cheng, Yi Chen, Naixia Zhang, Yanfen Fang, Youhong Hu   +13 more
semanticscholar   +1 more source

Dynamic changes in Beclin-1, LC3B and p62 at various time points in mice with temporary middle cerebral artery occlusion and reperfusion (tMCAO).

Brain Research Bulletin, 2021
Ischaemic stroke is attributable to cerebrovascular disease and is associated with high morbidity, disability, mortality and recurrence. Autophagy is a critical mediator and plays dual roles in ischaemic stroke.
Minzhen Deng, Xiaoqin Zhong, Zhijie Gao, Wen Jiang, Lilin Peng, Yucheng Cao, Zhongliu Zhou, Liping Huang   +7 more
semanticscholar   +1 more source

Neddylation modification stabilizes LC3B by antagonizing its ubiquitin-mediated degradation and promoting autophagy in skin

Proceedings of the National Academy of Sciences of the United States of America
Significance LC3B plays a pivotal role in autophagy flux and profoundly influences plentiful biological processes, including aging. While studies in Drosophila link reduced Atg8a expression to aging, regulation of LC3B protein levels in vertebrates ...
Linlin Xu, Xinxing Lyu, Yibo Wang, Li Ni, Pin Li, Piao Zeng, Qixia Wang, Yunhao Chang, Chenglong Pan, Qingxia Hu, Shuhong Huang, Ningning Dang   +11 more
semanticscholar   +1 more source

Tumor cell-derived LC3B+extracellular vesicles mediate the crosstalk between tumor microenvironment and immunotherapy efficacy in hepatocellular carcinoma via the HSP90α-IL-6/IL-8 signaling axis.

Clinical Immunology
BACKGROUND Inflammatory factors are being recognized as critical modulators of host antitumor immunity in liver cancer. We have previously shown that tumor cell-released LC3B positive extracellular vesicles (LC3B+ EVs) are responsible for malignant ...
Yong-Qiang Chen, Zhong-Song Man, Lu Zheng, Yue Zhang, Chengwen Zhao, Yuting Ma, Juan Zhou, Peng Wang, Yang Yu, Feng Gu, Guo-Ping Niu   +10 more
semanticscholar   +1 more source

LC3B-OPTN_phosphorylation_mutations

Repository of data and scripts for the publication : https://doi.org/10.1101/2023.09.30 ...
Papaleo, Elena, Utichi, Mattia
openaire   +1 more source

Functional variants in the LC3B gene promoter in acute myocardial infarction

Journal of Cellular Biochemistry, 2018
AbstractAcute myocardial infarction (AMI) is a common disease mainly caused by atherosclerosis, for which genetic causes remain largely unknown. Recently, low frequency and rare genetic variants have been proposed as risk factors. Autophagy has been involved in many cellular processes, such as lipid metabolism and inflammation, and implicated in human ...
Feng Gao, Qiang Su, Wentao Yang, Shuchao Pang, Shuai Wang, Yinghua Cui, Jinguo Zhang, Bo Yan   +7 more
openaire   +2 more sources