Results 71 to 80 of about 193,846 (93)
Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8 [PDF]
As obligate intracellular parasites, viruses rely on host machinery for their own reproduction. Viruses are therefore required to interact with a wide variety of host proteins, despite limitations in viral genome size.
Jespersen, Nathan E.
core
Three Sites are Better than One : Exploring Multivalency in LC8 Binding Partners
Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by
Clark, Sarah A.
core +1 more source
Journal of Molecular Biology, 2019 International audienceThe rabies and Ebola viruses recruit the highly conserved host protein LC8 for their own reproductive success. In vivo knockouts of the LC8 recognition motif within the rabies virus phosphoprotein (RavP) result in completely ...
Jean-Marie Bourhis +2 more
exaly +2 more sources
Crystal structure of human LC8 bound to a peptide from Ebola virus VP35
Journal of Microbiology, 2021 Zaire ebolavirus, commonly called Ebola virus (EBOV), is an RNA virus that causes severe hemorrhagic fever with high mortality. Viral protein 35 (VP35) is a virulence factor encoded in the EBOV genome.
Ho-chul Shin +2 more
exaly +2 more sources
Systematic identification of recognition motifs for the hub protein LC8 [PDF]
Life Science Alliance, 2019 Hub proteins participate in cellular regulation by dynamic binding of multiple proteins within interaction networks. The hub protein LC8 reversibly interacts with more than 100 partners through a flexible pocket at its dimer interface.
Cecilia Blikstad +2 more
exaly +2 more sources
The Mechanism of Dynein Light Chain LC8-mediated Oligomerization of the Ana2 Centriole Duplication Factor* [PDF]
Journal of Biological Chemistry, 2014 Centrioles play a key role in nucleating polarized microtubule networks. In actively dividing cells, centrioles establish the bipolar mitotic spindle and are essential for genomic stability.
Kevin C. Slep
exaly +2 more sources
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