Results 71 to 80 of about 116,535 (291)

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Medicamentos Não Sujeitos a Receita Médica de Dispensa Exclusiva em Farmácia em Portugal: Uma Oportunidade de Acesso Sub-Aproveitada?

Acta Médica Portuguesa, 2016
Introdução: Em 2013 foi introduzida em Portugal a classificação quanto à dispensa de medicamentos não sujeitos a receita médica de dispensa exclusiva em farmácia, uma subclassificação dos medicamentos não sujeitos a receita médica.
Ana Paula Martins, Elizabete Gonçalves, Ana Marcelo, Sergio Vilão, José Aranda Silva   +4 more
doaj   +1 more source

Image_3_Potassium deficiency diagnosis method of apple leaves based on MLR-LDA-SVM.jpeg

, 2023
IntroductionAt present, machine learning and image processing technology are widely used in plant disease diagnosis. In order to address the challenges of subjectivity, cost, and timeliness associated with traditional methods of diagnosing potassium ...
Jing Wang (6206297), Hua-Wei Yang (12467294), Hong-Jian Zhang (1892080), Kun Xu (116877), Ning Xu (52890), Lin-Lin Sun (7381460), Jin-Xing Wang (32715), Shuang-Xi Liu (3035316)   +7 more
core   +1 more source

Rapid Multiplex Antimicrobial Resistance Profiling and Bacterial Identification by LAP‐MALDI Mass Spectrometry Biotyping

Advanced Science, EarlyView.
Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair, Shabnam Iyer, Ian M. Jones, Rainer Cramer   +3 more
wiley   +1 more source

An industrial case study: QbD to accelerate time-to-market of a drug product

AAPS Open, 2021
The use of a Quality by Design (QbD) approach in the development of pharmaceutical products is known to bring many advantages to the table, such as increased product and process knowledge, robust manufacturing processes, and regulatory flexibility ...
Madalena Testas, Tiago da Cunha Sais, Leonardo Piccoli Medinilha, Katia Nami Ito Niwa, Lucas Sponton de Carvalho, Silvia Duarte Maia, Anderson Flores, Lígia Pedroso Braz, José Cardoso Menezes, Cássio Yooiti Yamakawa   +9 more
doaj   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

PENGANTAR NLP DAN TOPIK MODEL LDA [PDF]

Buku Pengantar NLP dan Topik Model LDA, dirancang untuk menjembatani kesenjangan pengetahuan di bidang pemrosesan bahasa alami (Natural Language Processing/NLP) dan pemodelan topik.
mustafid, mustafid, Widiantoro, Albertus Dwiyoga, Ridwan, Sanjaya   +2 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

WTL-CNN: a news text classification method of convolutional neural network based on weighted word embedding

Connection Science, 2022
The word embedding model word2vec tends to ignore the importance of a single word to the entire document, which affects the accuracy of the news text classification method.
Weidong Zhao, Lin Zhu, Ming Wang, Xiliang Zhang, Jinming Zhang   +4 more
doaj   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source