Results 241 to 250 of about 302,479 (284)

Prognostic Implication of LDL-C Variability and Its Association with Lipid-Lowering Strategies: Insights from the RACING and LODESTAR Trials. [PDF]

Yonsei Med J
Lee J, Bangalore S, Yun KH, Lee SH, Lee YJ, Lee SJ, Hong SJ, Ahn CM, Kim JS, Kim BK, Ko YG, Choi D, Jang Y, Hong BK, Hong MK.   +14 more
europepmc   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Multimodal Therapy Achieves Secondary Prevention LDL-C Targets in LDL-Receptor Null Homozygous Familial Hypercholesterolemia. [PDF]

JACC Case Rep
Alkhairy A, Xiang P, Khoo JK, Taylor CM, Francis GA.   +4 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Impact of LDL-C levels on severity and outcome of intracranial haemorrhage: a single-centre retrospective study. [PDF]

BMJ Neurol Open
Lee KP, Hsu LC.
europepmc   +1 more source

Exploring Uric Acid to HDL Ratio as a Long‐Term Biomarker for Diabetes Mellitus

Journal of Clinical Laboratory Analysis, EarlyView.
This study explores the predictive value of the serum uric acid to HDL cholesterol ratio (UHR) for diabetes mellitus (DM) using data from the decade‐long MASHAD cohort. Elevated UHR levels were significantly associated with increased DM risk, with gender‐specific thresholds identified through ROC analysis. These findings support UHR as a promising long‐
Rana Kolahi, Reza Khademi, Mahboobeh Ghasemzadeh Rahbardar, Niloofar Shabani, Habibollah Esmaily, Nazanin Akbari, Reyhane Alizadeh, Malihehsadat Abedsaeidi, Sara Saffar Soflaei, Majid Ghayour‐Mobarhan   +9 more
wiley   +1 more source

Association of sdLDL-C/LDL-C ratio with atherosclerotic cardiovascular disease: a case-control study. [PDF]

BMC Cardiovasc Disord
Yang Y, Yan T, Wang Y, Zhang Z, Li L, Zhang C, Cao N, Xia Y, Shen Y, Liu K, Fang X, Zhang X, Zhang N.   +12 more
europepmc   +1 more source

Serum proteins associated with LDL-C and non-HDL-C reduction in response to dietary interventions in the DASH and DASH-Sodium trials.

Food Funct
Kim H, Lichtenstein AH, Coresh J, Appel LJ, Rebholz CM.   +4 more
europepmc   +1 more source

HDL-C/LDL-C Ratio and All-Cause Mortality in Populations at High CVD Risk: A Prospective Observational Cohort Study. [PDF]

Chronic Dis Transl Med
Lin B, Ling Y, Zhou G, Ruan Z, Chen F, Chen S, Weng T, Zhu Y, Lin J, Yu L, Lin K.   +10 more
europepmc   +1 more source

Association between outdoor artificial light at night, circadian health, and LDL-C in intracranial artery atherosclerotic stenosis. [PDF]

Clin Epigenetics
Yang L, Wang Q, Zheng H, Wang Y, Miao Z, Li H, Yang Y.   +6 more
europepmc   +1 more source