Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park+6 more
wiley +1 more source
Some Interrelationships of Copper, Molybdenum, Zinc and Lead in the Nutrition of the Rat [PDF]
Louise F. Gray, G. H. Ellis
openalex +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi+26 more
wiley +1 more source
Peter Orebech, Fred Bossleman, Jes Bjarup, David Callies, Martin Chanock and Hanne Petersen, The Role of Customary Law in Sustainable Development (Cambridge: Cambridge University Press, 2005) - Book Review [PDF]
Reviewed by Roopa Madhav, LEAD Journal
doaj
Mesenchymal stem cells reduce the genotoxic effect of lead acetate in the testis of male rats and induce testicular cellular proliferation indicated by 16S rRNA sequence, increase the proliferation marker Ki-67 and a reduction in the apoptosis marker caspase-3. [PDF]
Allam M+7 more
europepmc +1 more source
Eutectic research. No. 1.—The alloys of lead and tin
Walter Rosenhain, P.A. Tucker
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THE EFFECTS OF LEAD, MERCURY, AND GOLD ON THE POTASSIUM TURNOVER OF RABBIT BLOOD CELLS [PDF]
C. R. B. Joyce+2 more
openalex +1 more source
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam+9 more
wiley +1 more source
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé+7 more
wiley +1 more source