Results 171 to 180 of about 754,901 (303)

Systematic computational strategies for identifying protein targets and lead discovery. [PDF]

RSC Med Chem
Kataria A, Srivastava A, Singh DD, Haque S, Han I, Yadav DK.   +5 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The International Adoption of Photovoltaic Energy Conversion Is Japan a Lead Market? [PDF]

This paper explores on the basis of a case study on photovoltaic energy conversion (PV) whether countries can actively create a lead market for new technology.
Marian Beise
core  

Biophysics-Guided Lead Discovery of HBV Capsid Assembly Modifiers. [PDF]

ACS Infect Dis
Fan Z, Pavlova A, Jenkins MC, Bassit L, Salman M, Lynch DL, Patel D, Korablyov M, Finn MG, Schinazi RF, Gumbart JC.   +10 more
europepmc   +1 more source

Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors. [PDF]

Microorganisms, 2016
Hanski L, Vuorela P.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity. [PDF]

ACS Med Chem Lett
Zuo H, Ru Y, Gao X, Chen H, Yan Y, Ma X, Liu X, Wang Y.   +7 more
europepmc   +1 more source

DNA-encoded chemical libraries: foundations and applications in lead discovery. [PDF]

Drug Discov Today, 2016
Zimmermann G, Neri D.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Price Discovery in Private Cash Forward Markets - The Case of Lumber

Cash forward contracting is a common, and often preferred, means of managing price risk for agribusinesses. Despite this, little is known about the performance of cash forward markets, in particular the role they play in price discovery.
Sanders, Dwight R., Manfredo, Mark R.
core