Results 81 to 90 of about 2,085,593 (298)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Inadvertent Lead Placement In The Left Ventricle: A Case Report And Brief Review

Indian Pacing and Electrophysiology Journal, 2009
Inadvertent lead placement in the left ventricle (LV) is an uncommon and often under-diagnosed complication of cardiac device implantation. Thromboembolic (TE) events are common and usually secondary to fibrosis or thrombus formation on or around the ...
David D. McManus, Mary-Lee Mattei, Karen Rose, Jason Rashkin, Lawrence S. Rosenthal   +4 more
doaj  

Characteristic extraction in numerical relativity: binary black hole merger waveforms at null infinity

, 2010
The accurate modeling of gravitational radiation is a key issue for gravitational wave astronomy. As simulation codes reach higher accuracy, systematic errors inherent in current numerical relativity wave-extraction methods become evident, and may lead ...
, , Ajith P, Ajith P, Ajith P, Allen G Camarda K Seidel E, Aylott B, B Szilágyi, Babiuc M, Baker J G van Meter J R McWilliams S T Centrella J Kelly B J, Bishop N, Bishop N T, Bishop N T, Brügmann B González J A Hannam M Husa S Sperhake U Tichy W, Buonanno A Cook G B Pretorius F, C Reisswig, Cook G B, D Pollney, Gonzalez J A Sperhake U Bruegmann B, Goodale T Allen G Lanfermann G Massó J Radke T Seidel E Shalf J, Gómez R, Herrmann F, N T Bishop, Nagar A, Pollney D Reisswig C Dorband N Schnetter E Diener P, Pollney D Reisswig C Schnetter E Dorband N Diener P, Reisswig C, Reisswig C, Rezzolla L, Schnetter E, Schnetter E, Smarr L, Szilágyi B   +32 more
core   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Strong monogamies of no-signaling violations for bipartite correlation Bell inequalities

, 2014
The phenomenon of monogamy of Bell inequality violations is interesting both from the fundamental perspective as well as in cryptographic applications such as the extraction of randomness and secret bits.
Horodecki, Paweł, Ramanathan, Ravishankar   +1 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

THE ALTERNATIVE APPROACH FOR PACING LEADS IMPLANTATION AND EXTRACTION

Медицинский вестник Юга России, 2017
Analysingthe example of unusual case of a successful direct constant His bundle pacing, we would like to draw specialist’s attention to details of procedure and some important electrophysiological particularities we have come across during operation ...
A. V. Ponomarev, D. V. Safonov, F. V. Sklyarov, G. V. Chudinov, N. A. Peskov, A. A. Tatyanchenko, V. V. Korshunov   +6 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

POVERTY AND THE MANAGEMENT OF NATURAL RESOURCES:A MODEL OF SHIFTING CULTIVATION [PDF]

It is frequently asserted in the environment/development literature that severe poverty causes the neglect of worthwhile investments, resulting in deforestation and other resource degradation.
Ed Balsdon
core