Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay +15 more
wiley +1 more source
“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez +29 more
wiley +1 more source
A survey of beneficial insects in Southeast USA sesame (Lamiales: Pedaliaceae) fields. [PDF]
Todd LE, Suchoff DH, Levenson HK.
europepmc +1 more source
Endothelial Cell Proteins as Biomarkers in Susac Syndrome
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin +11 more
wiley +1 more source
A proposal for expedited stem cell transplantation for TP53-mutant myelodysplastic neoplasms and acute myeloid leukemia. [PDF]
Patel SA, Devine SM, Cerny J.
europepmc +1 more source
Objective Frailty occurs prematurely in rheumatoid arthritis (RA) and is associated with poor health outcomes. We compared the performance of four frailty instruments, including a pragmatic alternative measure using chair sit‐to‐stand (STS), and evaluated their abilities to predict poor health outcomes.
Kylie E. Riggles +14 more
wiley +1 more source
Assessment of the content validity of the Oswestry Disability Index (ODI) in patients with Degenerative Disc Disease (DDD): a qualitative study. [PDF]
Powers JH +4 more
europepmc +1 more source
Speech Perception and Preparation Are Supported by Distinct Neural Dynamics Across Development. [PDF]
Liu Y, Wray AH, Chang SE.
europepmc +1 more source
Development and validation of social compensation design scale for urban older users in the context of smart-home social media. [PDF]
Ma K +5 more
europepmc +1 more source
Effect of resin infiltration system and pit-fissure sealant on white spot lesion: An <i>in vitro</i> study. [PDF]
Khan A +5 more
europepmc +1 more source

