Results 141 to 150 of about 3,949,457 (265)

Optimal lead time for treatment of infantile epileptic spasms syndrome-a secondary data analysis. [PDF]

Transl Pediatr
Ge W, Pang P, Zhang Z, Wan L, Yang G.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evaluation of visual patient predictive for enhancing level 3 situation awareness: protocol for a multicentre randomised computer-based simulation and diagnostic accuracy study (true positive rate, precision, average lead time). [PDF]

BMJ Open
Hunn CA, Bruns H, Sahli S, Wachtendorf L, Schäfer J, Schwerin S, Delis A, Kalisch M, Dugac G, Rahrisch A, Ebensperger M, Karimitar A, Massoth G, Neuhaus C, Dubatovka A, Nöthiger CB, Gasciauskaite G, Roche TR, Tscholl DW.   +18 more
europepmc   +1 more source

Time for a lead-time definition? Author response to 'Why the length of recurrence free survival or "lead-times" can be misleading. Comment on: Callesen LB, Takacova T, Hamfjord J, et al. Circulating DNA in patients undergoing loco-regional treatment of colorectal cancer metastases: a systematic review and meta-analysis'. [PDF]

Ther Adv Med Oncol, 2023
Spindler KG, Callesen LB, Arnold D.
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Lead-Time Corrected Effect on Breast Cancer Survival in Germany by Mode of Detection. [PDF]

Cancers (Basel)
Schumann L, Hadwiger M, Eisemann N, Katalinic A.   +3 more
europepmc   +1 more source

Infantile spasms: Etiology, lead time and treatment response in a resource limited setting. [PDF]

Epilepsy Behav Rep, 2020
Surana P, Symonds JD, Srivastava P, Geetha TS, Jain R, Vedant R, Murugan S, Mahalingam S, Bhargava V, Goyal P, Zuberi SM, Jain V.   +11 more
europepmc   +1 more source

Measurable residual disease monitoring provides insufficient lead-time to prevent morphologic relapse in the majority of patients with core-binding factor acute myeloid leukemia. [PDF]

Haematologica, 2021
Puckrin R, Atenafu EG, Claudio JO, Chan S, Gupta V, Maze D, McNamara C, Murphy T, Shuh AC, Yee K, Sibai H, Minden MD, Wei C, Stockley T, Kamel-Reid S, Schimmer AD.   +15 more
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Method of primary breast cancer detection and the disease-free interval, adjusting for lead time. [PDF]

J Natl Cancer Inst
de Munck L, Eijkelboom AH, Otten JDM, Broeders MJM, Siesling S.   +4 more
europepmc   +1 more source