Results 151 to 160 of about 606,542 (313)

LEADER 5 : prevalence and cardiometabolic impact of obesity in cardiovascular high-risk patients with type 2 diabetes mellitus: baseline global data from the LEADER trial

, 2016
: Background: Epidemiological data on obesity are needed, particularly in patients with type 2 diabetes mellitus (T2DM) and high cardiovascular (CV) risk.
Vidal, J., Van Gaal, Luc, Masmiquel, L., Leiter, L. A., et al.   +4 more
core  

Dual regulation of the receptor-like kinase BIR1 involves site-directed transcript cleavage and 5'-leader-mediated translational control. [PDF]

PLoS Pathog
Guzmán-Benito I, Robinson C, Donaire L, Fernández-Calvino L, Franco-Zorrilla JM, Niu R, Xu G, Merchante C, Llave C.   +8 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Superior outcomes with offspring B-leader-matched haploidentical versus older matched sibling donors in AL/MDS patients aged ≥40 years. [PDF]

Front Immunol
Wei Y, Tang J, Yang R, Shao Y, Luan S, Wang L, Wang L, Li F, Wu Y, Qian K, Peng B, Zhang H, Ge D, Fang Y, Huang L, Liu Q, Dou L, Liu D.   +17 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Police need wellness checks too: Embedding a culture of wellness and resilience in policing

Journal of Community Safety and Well-Being, 2023
Lauren Jackson, Michelle Theroux
doaj   +1 more source

Leader bottom-line mentality and employees' innovative work behavior: the role of workplace spirituality and value congruence. [PDF]

Front Psychol
Zhou Y, Li T, Li X.
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Leader-Selection Mechanisms and Matching Protocols in Public Goods Games: Evidence from the Laboratory. [PDF]

Behav Sci (Basel)
Chen D, Liu J, Zhang W, Zheng J.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source