Results 241 to 250 of about 606,542 (313)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Solving the 3D UAV Path Planning Problem Using an Improved Multi-Leader Multi-Objective Whale Optimization Algorithm. [PDF]

Biomimetics (Basel)
Tu B, Bao J, Zhou H, Huo Y, Han X, Hui N.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Green Planet: development and early evaluation of a novel method for climate actions in clinical practice. [PDF]

BMC Health Serv Res
Stabel LS, Kristensson D, Hasson H, Schettini G, Sävblom C, Mazzocato P.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The influence of moral leadership (in)congruence on negative workplace gossip is explained by perceived hypocrisy. [PDF]

Sci Rep
Chen Q, Liu Z, Shi G.
europepmc   +1 more source

Involvement of tRNA thiolation in uORF-mediated translational regulation during Xylogenesis in Arabidopsis thaliana. [PDF]

Plant Cell Physiol
Nishii Y, Araki D, Saraumi M, Takahashi T.   +3 more
europepmc   +1 more source

Event-Triggered Adaptive Consensus Control for Nonlinear Multi-Agent Systems with Prescribed Performance and Full-State Constraints. [PDF]

Sensors (Basel)
Wang W, Chen Q, Xu H, Chen Z, Wang L, Su D, Zhu X.   +6 more
europepmc   +1 more source

Is It About Hierarchy? An Evolutionary Account of the Burnout-Depression Overlap. [PDF]

Behav Sci (Basel)
Garcia HA, Reiss JJ.
europepmc   +1 more source