Results 211 to 220 of about 1,718,225 (251)

Tobacco-free cities: a qualitative evaluation of the tobacco control programmes in Chinese cities, 2009-2018. [PDF]

BMJ Open
Zhao Y, Qian C, Fang L, Zheng P, Duan Z, Koplan J, Redmon P, Eriksen M.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

30 years of ENLP: developing nutrition leaders for positive change - lessons learnt and ways forward. [PDF]

J Nutr Sci
Ivanović N, Dobani S, Neill HR, Webb RJ, Gallagher AM.   +4 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Clinical and cost-effectiveness of oral versus intramuscular glucocorticoids in rheumatoid arthritis: protocol for a multicentre randomised controlled trial with economic evaluation and qualitative sub-study (LEADER trial). [PDF]

BMJ Open
Cook JA, Wilson N, Wilkins K, Staniland K, Ekang I, Azmi S, Heaney L, Gavan SP, Elliott RA, Wilson RJ, Calvert C, Francis A, Williams JAE, Turner A, Zimmermann A, Richards D, Barton A, Bluett J, LEADER trial network.   +18 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

'What Matters to Staff Programme': eight steps to improve staff well-being at work. [PDF]

BMJ Lead
Turner K, Longmate R, Coy-Terry J, Dai M.   +3 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Protect her future: Lessons learned from a school and community engagement initiative for HPV vaccine awareness in Lilongwe, Malawi. [PDF]

Hum Vaccin Immunother
Lubanga AF, Nyasulu W, Stande M, Kamanga M, Kamanga F, Katoleza E, Manja LD, Mwalwanda A.   +7 more
europepmc   +1 more source