Results 181 to 190 of about 26,443 (254)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Job satisfaction among medical assistants in German general practice: a qualitative study of social, structural and personal factors. [PDF]

BMC Prim Care
Kersten S, Hohmann E, Piotrowski A, Lepper AK, Dehnen D, Pentzek M, Weissbach S, Schweizer J.   +7 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Student Leadership Development in a Gen-AI Higher Education Landscape: Four Imperatives for the Future. [PDF]

New Dir Stud Leadersh
Acheson K.
europepmc   +1 more source

Potential profile and influencing factors of feedback-seeking behavior among nursing interns during the early stages of internships: a multicenter cross-sectional study. [PDF]

Front Med (Lausanne)
Xiong C, Wang S, Guo P, Lei Y, Xiao Y, Chen Q, Guo L, Zhang Z, Liu L.   +8 more
europepmc   +1 more source

Factors associated with career decision-making difficulties among undergraduate nursing students: a latent profile analysis. [PDF]

Front Med (Lausanne)
Zhou H, Huang L, Fu Z, Li L, Huang Z, Zhang J, Tang M, Wang X, Sui W, Zhuang Y.   +9 more
europepmc   +1 more source

Bridging language and data: Transforming agricultural curricula for data analytics through linguistic insights. [PDF]

PLoS One
Xu Z, Ahn J, Ma S, Adyemi AE, Choudhury FH, Zhuang X, Landaverde R, Wingenbach G.   +7 more
europepmc   +1 more source