Results 241 to 250 of about 60,647 (303)

Topology‐Aware Deep Learning on Higher‐Order Structures for Drug Response Prediction

Advanced Science, EarlyView.
We present TopDr, a topology‐aware deep learning framework that encodes both drugs and cell lines as multiscale simplicial complexes, capturing interactions at the 0‐, 1‐, and 2‐simplex levels. By jointly integrating local higher‐order neighborhoods and global topological structures, TopDr generates enriched representations for sensitivity prediction ...
Cong Shen, Guancen Lin, Chuan‐Shen Hu, Yong Wang   +3 more
wiley   +1 more source

QTL mapping, validation, and candidate gene predicting for maize plant architecture traits via bulked segregant analysis plus linkage analysis with F₂ population. [PDF]

BMC Plant Biol
Wang S, Wang Y, Li X, Ge B, Su C.
europepmc   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Drought adaptation in spring wheat seedlings relies on coordinated deep root architecture and cortical tissue allocation. [PDF]

Front Plant Sci
Li X, Guo C, Bai C, Wang S, Gao X, Huo J, Cui F, Fan H, Bao X, Zhao C.   +9 more
europepmc   +1 more source

A Symmetric Cogeneration Fuel Cell for Coupled Production of Hydrogen, Ammonia and Formate

Advanced Science, EarlyView.
A symmetric cogeneration fuel cell integrating value‐added chemical synthesis with electricity generation by coupling formaldehyde oxidation with the nitrate reduction was developed. This work highlights the broader potential of symmetric cogeneration fuel cells as a general platform for rational reaction pairing, offering a practical pathway to lower ...
Yingjie Song, Peimiao Zou, Renhang Wang, Qi Zhang, Yisong Han, Christopher Waldron, Marc Walker, Ben G. Breeze, Shanwen Tao   +8 more
wiley   +1 more source

Federated learning with dynamic weighted aggregation for multi-crop disease detection: a hybrid CNN-transformer approach. [PDF]

Front Artif Intell
Shashank R, Bhavadharini RM.
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Research on maize growth simulation and organ morphology co-modeling driven by multimodal data fusion. [PDF]

Front Plant Sci
Zhenghui Z, Ke Z, Yan Z, Pingzeng L, Shiwei X, Yong Z.   +5 more
europepmc   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Rose leaf disease classification and severity estimation using an interpretable vision transformer-based multi-task framework. [PDF]

BMC Plant Biol
Bohra M N, Patil AR, Thorve OH, Shahade AK, Deshmukh PV, Patil S, Kotecha K.   +6 more
europepmc   +1 more source