Results 31 to 40 of about 37,143 (302)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A Threshold Line for Safe Geologic CO2 Storage Based on Field Measurement of Soil CO2 Flux
C, 2021 Carbon capture and storage (CCS) is an established and verified technology that can implement zero emissions on a large enough scale to limit temperature rise to below 2 °C, as stipulated in the Paris Agreement.
Takashi Kuriyama +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Structure health monitoring of concrete structures using magnetic flux leakage
, 2022 Reinforcing bar, usually made of steel, is widely used in civil structures to increase the tensile strength of concrete. Heatinduced delayed expansion and corrosion expansion resulting in rust occupies a greater volume than rebar.
Wang, Q., Zhang, Y.H., Huang, S.L.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Zhejiang dianliCurrent research lacks a comprehensive analysis of magnetic flux leakage patterns caused by transformer winding defects， which complicates defect detection.
LU Yingqiang +3 more
doaj +1 more source
Studies in Electrical Machines & Wind Turbines associated with developing Reliable Power Generation [PDF]
, 2012 The publications listed in date order in this document are offered for the Degree of Doctor of Science in Durham University and have been selected from the author’s full publication list.
TAVNER, PETER,JOHN
core
Inspection of Gas Pipelines Using Magnetic Flux Leakage Technology
, 2017 Magnetic non-destructive testing methods can be classified into the earliest methods developed for assessment of steel constructions. One of them is the magnetic flux leakage technology.
K. Warnke, Z. Usarek
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source