Results 41 to 50 of about 283,565 (299)

Present situation and development trend of control and protection technology for mine-used combined switch

Gong-kuang zidonghua, 2019
Present situation of control and protection technology for mine-used combined switch was introduced from aspects of short circuit protection, overload protection, leakage lockout and leakage protection, transient overvoltage protection and temperature ...
YANG Fan, CHEN Jiang
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Radiation environment for rendezvous and docking with nuclear rockets [PDF]

, 1972
Radiation environment data for the NERVA engine are provided which may be utilized in estimating radiation exposures associated with various space maneuvers.
Lindsey, B. A., Rogers, D. R., Warman, E. A.   +2 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Research on Active Defense System for Transformer Early Fault Based on Fiber Leakage Magnetic Field Measurement

Energies
In the early faults of transformer windings, there are obvious variation characteristics of the spatial leakage magnetic field. Taking the leakage magnetic field as the fault characteristic quantity can establish an active defense system for transformer ...
Junchao Wang, Yaqi Liu, Jian Mao, Shaoyong Liu, Zhixiang Tong, Xiangli Deng, Wenbin Tan   +6 more
doaj   +1 more source

Protecting Digital Dignitas: Highlighting Legal Protection and Responsibility in Personal Data Security Crime in Indonesia's Online Marketplace World

Mahadi, 2023
Today the development of technology is increasingly massive and gave birth to a form of intelligence called Artificial Intelligence/AI. Economic potential and threats of personal data leakage awaiting immediate investigation.
Dinda Yunisa, Adelina Mariani Sihombing, Chelsea Mutiara Putri, Nurul Hasanah   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

METHODOLOGY FOR ASSESSING THE SECURITY OF INFORMATION PASSED THROUGH THE TECHNICAL CHANNELS OF A SPECIAL-PURPOSE INFORMATISATION OBJECT

Вестник Дагестанского государственного технического университета: Технические науки, 2020
Objectives. In order to determine the security of a special-purpose informatisation object, it is necessary to calculate the effectiveness indicators of information security (IS) measures aimed at preventing unauthorised access (UA) threats associated ...
E. A. Rogozin, D. G. Silka, O. A. Gulyaev   +2 more
doaj   +1 more source