Results 91 to 100 of about 40,859 (264)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Lean Green Tendency

Brazilian Journal of Operations & Production Management
Lean philosophy and Green practices have been identified as management approaches that allow organizations to reach better economic and environmental results. Nevertheless, some authors argue that results can be enhanced with the integration of the Lean and Green practices. This synchronous effort has led to the developing a new Lean philosophy branch,
Cláudia Sousa e Silva, Sara Azevedo, Maria Fonseca   +2 more
openaire   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

PERANCANGAN MODEL PENGUKURAN KINERJA LEAN DAN GREEN RANTAI PASOK SEMEN SECARA TERINTEGRASI

Jurnal Optimasi Sistem Industri, 2017
PT. Semen Padang is one of the reputable cement companies in Indonesia which is producing types of cement. Implementation of supply chain concept in PT. Semen Padang is very important to satisfy customers and stakeholders requirement.
Dina Rahmayanti, Utari Putri
doaj  

GREEN LEAN METHODOLOGY: ENTERPRISE ENERGY MANAGEMENT FOR INDUSTRIAL COMPANIES [PDF]

Annals: Series on engineering sciences (Academy of Romanian Scientists), 2013
The purpose of this article is to show the usefulness of Lean Manufacturing techniques when approaching the environmental issues. Green Lean Methodology presentation in seven steps with afferent tools and techniques provides a practical framework.
Alin POSTEUCĂ
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Perancangan Model Pengukuran Kinerja Lean dan Green Rantai Pasok Semen Secara Terintegrasi

Jurnal Optimasi Sistem Industri, 2016
PT. Semen Padang is one of the reputable cement companies in Indonesia which is producing types of cement. Implementation of supply chain concept in PT. Semen Padang is very important to satisfy customers and stakeholders requirement.
Dina Rahmayanti, Utari Putri
doaj  

Effects of lean and green supply chain management practices on the performance of Hungarian manufacturing companies

Discover Sustainability
Ensuring long-term sustainability and maintaining competitiveness are critical challenges for manufacturing enterprises. In this study the authors investigated the hypothesis that the adoption of Lean and GSCM practices affects corporate performance ...
Tímea Gál, Veronika Fenyves, Margit Csipkés, László Terjék, Sándor Kovács, Erzsébet Buglyó-Nyakas   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source