Results 171 to 180 of about 11,060,629 (282)

Commit: BitBIRCH: efficient clustering of large molecular libraries.

Digit Discov
Pickering I, Zsigmond K, Pérez KL, Lžičař M, Miranda-Quintana RA.   +4 more
europepmc   +1 more source

Regional fat distribution as a novel predictor of fracture risk in inflammatory bowel disease: a DXA-based cohort study. [PDF]

BMJ Open Gastroenterol
Suntharalingam S, Bukhari M.
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Fat and lean mass changes during incretin-based therapy with structured exercise and nutritional support: A retrospective real-world pilot study. [PDF]

Obes Pillars
Kucuk Yetgin M, Gletsu-Miller N, Chapman RR, Gelber E, Snyder J, Gregg D, Nabhan D.   +6 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Prevalence of Non-Alcoholic Fatty Liver Disease by Ultrasonographic Assessment in Lean Individuals With Diabetes. [PDF]

Cureus
D G NK, Gowda M, Pai M.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Intraoperative Methadone for Postoperative Pain Control in Living Donor Hepatectomy. [PDF]

J Transplant
Seibert A, Puri D, Whong Z, Kim B, Alsaadawi R, Kang L, Kim C, Lee SD, Kumaran V, Pancholia S, Navarrete S.   +10 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Is plant-based protein supplementation as effective as whey protein? A systematic review and meta-analysis in untrained adults undergoing resistance training. [PDF]

J Int Soc Sports Nutr
Callegari IOM, Silva GM, Oliveira AG.
europepmc   +1 more source