Results 121 to 130 of about 3,455,968 (292)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating lean in healthcare [PDF]

The overarching aim of this thesis is to evaluate Lean implementation in the English NHS. Against a background of financial austerity measures and the ostensible widespread adoption of Lean in the UK public sector, and particularly by healthcare ...
Burgess, Nicola
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Association of estrogen receptor alpha gene PvuII and XbaI polymorphisms with obesity-related phenotypes and body composition in Iranian children and adolescents: a cross-sectional study

Egyptian Journal of Medical Human Genetics
Background Obesity in children is a serious health issue. In this study, we investigated the association of ESR1 rs2234693 (PvuII) and rs9340799 (XbaI) with obesity-related phenotypes and body composition in Iranian children and adolescents.
Nima Montazeri-Najafabady, Mohammad Hossein Dabbaghmanesh   +1 more
doaj   +1 more source

Glucagon-like peptide-1 receptor agonists and muscle: interpreting lean mass changes in clinical care

Global Cardiology
Skeletal muscle supports mobility and metabolic reserve. Low muscle reserve is common in obesity, type 2 diabetes mellitus (T2DM), and metabolicassociated steatotic liver disease, where myosteatosis and insulin resistance are linked to poorer strength ...
Muhammad Sameer Arshad, Maaz Ali, Asad Ali Ahmed Cheema, Stefan D. Anker, Andrew J.S. Coats   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Resistance Training or Whey Protein as an Intervention to Preserve Lean Mass in Men Observing Ramadan

Physiologia
Background: Individuals observe Ramadan fasting for ~11 h per day for 28–30 days, which can negatively affect lean mass. Resistance training or increased protein intake can potentially preserve lean mass in these individuals.
Ahmed S. Amjed, Arwa Abdelhakiem, Natalie Allen, Cory Brune, Matthew L. Sokoloski, Ryan A. Gordon   +5 more
doaj   +1 more source

Lean Mass [PDF]

, 2020
openaire   +1 more source