FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Body composition and physical function in the Women's Health Initiative Observational Study
Preventive Medicine Reports, 2018 Physical function is critical for mobility and quality of life. We hypothesized that higher total lean mass is associated with higher physical function, and body fat inversely associated, among postmenopausal women.
Jennifer W. Bea +8 more
doaj +1 more source
Body Cell Mass and Lean Body Mass in the Growing Beagle
Experimental Biology and Medicine, 1973 SummaryThe lean body mass (LBM) was considered equivalent to fat-free wet weight (FFWW), and it decreased from 97% of body weight at birth to 85% when the pups were 1.5 mo old, after which it did n...
H P, Sheng, R A, Huggins
openaire +2 more sources
Maternal glucose and fatty acid kinetics and infant birth weight in obese women with type 2 diabetes [PDF]
, 2016 The objectives of this study were 1) to describe maternal glucose and lipid kinetics and 2) to examine the relationships with infant birth weight in obese women with pregestational type 2 diabetes during late pregnancy.
Cade, W. Todd +4 more
core +2 more sources
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
FRI017 Precision-engineered Activin And GDF Ligand Trap HS235: A Novel Lean Mass-preserving Treatment for Obesity [PDF]
, 2023 Gauthier Schang +9 more
openalex +1 more source
Serum insulin-like growth factor binding protein-2 levels as an indicator of functional ability in elderly men [PDF]
, 2003 BACKGROUND: In a cross-sectional study in 403 healthy, independently living elderly men (mean age 78 years), we determined which are the main physiological determinants of functional ability in the elderly, and which components of the ...
Beld, A.W. (Annewieke) van den +4 more
core +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Effects of Resistance Exercise on Total and Regional Body Composition in Overweight Sedentary Males
Spor Bilimleri Araştırmaları DergisiThe purpose of this study was to examine the effects of 12 weeks of resistance exercise training on body weight (BW), body mass index (BMI), total fat mass (FM), trunk, arm, and leg fat mass, and total lean body mass (LBM), arm, and leg lean mass of ...
Halil Tanır +3 more
doaj +1 more source