Results 31 to 40 of about 356,546 (344)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
APRENDENDO ADMINISTRAÇÃO EM LABORATÓRIO: DESAFIOS E FRUSTRAÇÕES DE UMA EXPERIÊNCIA
Revista Gestão Universitária na América Latina, 2012 In this paper, we describe and reflect on the experience of the authors in setting up a new model of learning environment in management education in a Brazilian University.
Jorge Alberto dos Santos, Simone Martins
doaj
Journal of Education and TeachingThis study examines the implementation of student-centered learning at Soran University in the Kurdistan Region and identifies factors that limit its adoption.
Saied Qadir Faqe Ibrahim +1 more
doaj +1 more source
Educar, 2008 En los últimos años, se ha debatido mucho sobre el nuevo modelo pedagógico que promueve el nuevo espacio de educación superior. Este artículo recoge la experiencia del Programa UNIGIS de formación a distancia en SIG, que se imparte desde la Universidad ...
Gemma Boix, Suani Armisen
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Innovative Higher Education Approaches for Power System Courses
Education Sciences, 2023 Higher education plays a crucial role in modern society and in emerging energy systems, due to the rising complexity of the phenomena and the interplay among various layers (physical, cyber, social and economic).
Ettore Bompard +4 more
doaj +1 more source
Learning by doing in contests [PDF]
, 2010 We introduce learning by doing in a dynamic contest. Contestants compete in an early round and can use the experience gained to reduce effort cost in a subsequent contest.
Clark, Derek J., Nilssen, Tore
core +1 more source