Results 41 to 50 of about 328,942 (275)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Methodological Learning-by-Doing

Grounded Theory Review: An International Journal, 2009
The experience of minus mentoring in learning classic grounded theory (CGT) is shared by many people over the world. The aim of this article is to share experiences of learning and using CGT.
Pernilla Pergert
doaj  

Medienkompetenz durch ‹Learning by Doing›?

MedienPädagogik: Zeitschrift für Theorie und Praxis der Medienbildung
Lehrkräfte an berufsbildenden Schulen sollen über grundlegende Medienkompetenzen verfügen, um ihren Schüler:innen den Umgang mit digitalen Endgeräten medienpädagogisch zu vermitteln und deren Fähigkeiten und Fertigkeiten in diesem Bereich zu stärken ...
Johannes Schäfers
doaj   +1 more source

Reflection in Learning to Write an Academic Text. How Does Reflection Affect Observational Learning and Learning-by-Doing in a Research Synthesis Task?

Frontiers in Education, 2019
In this study, we focused on the effect of reflection on different instructional methods, comparing observational learning and learning by doing, in the context of an academic writing task.
Janneke van der Loo, Emiel Krahmer, Marije van Amelsvoort   +2 more
doaj   +1 more source

The Development of Research Process for Pre-service Physics Teachers in Science Classroom Action Research Course using Learning by Doing [PDF]

Journal of Humanities and Social Sciences Mahasarakham University, 2022
The objectives of this research were to 1) study the knowledge, understanding and competency in classroom research of preservice physics teachers who had received hands-on instructional activities, and 2) study the satisfaction of hands-on instructional ...
Duangjan kaewkongpan, Chisapath hoothong
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Unravelling learning by doing [PDF]

, 2009
Scheele, F. [Promotor]Vleuten, C.P.M.
Teunissen, P.W.
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Development of Student Worksheets for Economics Subjects Based on Learning by Doing

Tekno - Pedagogi
This research aims to develop student worksheets based on Learning by Doing in learning Economics subjects for class X students at Senior High School 5 Jambi City.
Suratno Suratno
doaj   +1 more source