Results 51 to 60 of about 356,546 (344)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

New Ways to Learn Geography – Challenges of the 21st Century

open access: yesQuaestiones Geographicae, 2018
The aim of the article is to get a closer overview of the non-instructional methods of the teaching-learning process of geography. To achieve this goal, the results of the international project Borderland: Border Landscapes Across Europe (undertaken in ...
Markuszewska Iwona   +2 more
doaj   +1 more source

LearningML: A Tool to Foster Computational Thinking Skills Through Practical Artificial Intelligence Projects

open access: yesRED. Revista de Educación a Distancia, 2020
The use of artificial intelligence systems in multiple levels of society offers new and thriving opportunities, but also introduces new risks and ethical issues that should be dealt with.
Juan David Rodríguez García   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

LEARNING BY DOING IN AN AMBIGUOUS ENVIRONMENT [PDF]

open access: yes
We experimentally test whether risk aversion or ambiguity aversion can explain decisions in a learning by doing game. We first measure subjects' preferences toward risk and ambiguity, and then use these measures to predict behavior in the game.
Jim Engle-Warnick   +1 more
core   +3 more sources

Knowledge Transfer as a Leverage of Change, the Case of the Public Prosecutor Office of Naples

open access: yesInternational Journal for Court Administration, 2013
The public prosecutor’s office of Naples is the biggest prosecutorial institution in Italy. Because of its size,  its visibility, and its location in Naples, the PPO it is an  interesting and difficult case from an organization development perspective ...
Daniela Piana
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Using Theories of Change to inform implementation of health systems research and innovation: experiences of Future Health Systems consortium partners in Bangladesh, India and Uganda

open access: yesHealth Research Policy and Systems, 2017
Background The Theory of Change (ToC) is a management and evaluation tool supporting critical thinking in the design, implementation and evaluation of development programmes.
Ligia Paina   +10 more
doaj   +1 more source

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